SPECTRUM OF BETA-THALASSEMIA MUTATIONS IN THE POPULATION OF SAUDI-ARABIA

被引：9

作者：

HASOUNAH, FH

SEJENY, SA

OMER, JA

OLD, JM

OLIVER, RWA

机构：

[1] UNIV SALFORD,DEPT BIOL SCI,SALFORD M5 4WT,LANCS,ENGLAND

[2] JOHN RADCLIFFE HOSP,INST MOLEC MED,OXFORD OX3 9DU,ENGLAND

[3] ABDULAZIZ UNIV HOSP,DEPT HAEMATOL,JEDDAH,SAUDI ARABIA

来源：

HUMAN HEREDITY | 1995年 / 45卷 / 04期

关键词：

BETA-THALASSEMIA; DNA MUTATIONS; SAUDI ARABIA;

D O I：

10.1159/000154294

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

A study of beta-thalassaemia alleles in 29 beta-thalassaemia homozygotes and HbS/beta-thalassaemia patients from western Saudi Arabia using the allele-specific priming technique of the polymerase chain reaction revealed a total of five mutations, The spectrum of mutations found in the western region is significantly different to that previously reported in the eastern region, and brings the total number of mutations observed in Saudi Arabian nationals to ten, A comparison of the types and frequencies of the Saudi Arabian mutations with those found in neighbouring Arab countries is made.

引用

页码：231 / 234

页数：4

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