2-IMINO-1,3,4-THIADIAZOLE DERIVATIVES OF GABA AS GABA-A ANTAGONISTS

被引：5

作者：

ALLAN, RD

APOSTOPOULOS, C

RICHARDSON, JA

机构：

[1] Department of Pharmacology, University of Sydney, NSW

来源：

AUSTRALIAN JOURNAL OF CHEMISTRY | 1990年 / 43卷 / 10期

关键词：

D O I：

10.1071/CH9901767

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

New heterocyclic derivatives of GABA, with a GABA moiety on the 3 position of a 2-imino-1, 3, 4- thiadiazole ring, have been readily prepared by alkylation of 2-amino-5-aryl-1, 3, 4-thiadiazoles in dimethylformamide. They are active as GABAA antagonists, inhibiting the action of gaba on the guinea-pig ileum about 5 times less potently than bicuculline. © 1990 ASEG.

引用

页码：1767 / 1772

页数：6

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[2]

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[3]

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