A NEW APPROACH TO SYNTHESIS OF OLIGONUCLEOTIDES WITH 3'PHOSPHORYL GROUPS

被引：31

作者：

GRYAZNOV, SM ^{[1
]}

LETSINGER, RL ^{[1
]}

机构：

[1] NORTHWESTERN UNIV,DEPT CHEM,EVANSTON,IL 60208

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 29期

关键词：

MASKED ACID-LABILE LINKER; CYANOETHYL PHOSPHORAMIDATE TETHER; SOLID SUPPORT SYNTHESIS;

D O I：

10.1016/S0040-4039(00)74669-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A convenient method for synthesizing oligonucleotide 3'phosphates utilizes a diester phosphoramidate linker obtained by condensing a nucleoside phosphoramidite reagent with an aminoalkyl solid support. Oligomer release is effected by NH3;H+.

引用

页码：4127 / 4128

页数：2

共 7 条

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