ACTIVATED, CYTOTOXIC LYMPHOCYTES IN SYSTEMIC VASCULITIS

被引：7

作者：

BLANN, AD

SCOTT, DGI

机构：

[1] UNIV HOSP S MANCHESTER,DEPT SURG,MANCHESTER M20 8LR,LANCS,ENGLAND

[2] NORWICH & NORFOLK HOSP,DEPT RHEUMATOL,NORWICH NR1 3SR,NORFOLK,ENGLAND

来源：

RHEUMATOLOGY INTERNATIONAL | 1991年 / 11卷 / 02期

关键词：

LYMPHOCYTE CYTOTOXICITY; RHEUMATOID DISEASES; ENDOTHELIAL CELLS; FIBROBLASTS;

D O I：

10.1007/BF00291148

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Peripheral blood lymphocytes from some patients with rheumatoid vasculitis and giant cell arteritis were cytotoxic in vitro towards endothelial cells, but not fibroblasts. Use of cell surface markers and cell density showed that cytotoxicity correlated with numbers of HLA-DR bearing cells, but not with cells bearing CD3, the transferrin receptor, or less dense lymphocytes. We concluded that activated, cytotoxic lymphocytes were present in the peripheral blood of a sub-set of patients with vasculitis.

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页码：69 / 72

页数：4

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