CHROMOSOMAL-ABNORMALITIES IN WALDENSTROMS MACROGLOBULINEMIA

被引：24

作者：

CARBONE, P ^{[1
]}

CARADONNA, F ^{[1
]}

GRANATA, G ^{[1
]}

MARCENO, R ^{[1
]}

CAVALLARO, AM ^{[1
]}

BARBATA, G ^{[1
]}

机构：

[1] OSPED V GERVELLO,DIV EMATOL,PALERMO,ITALY

来源：

CANCER GENETICS AND CYTOGENETICS | 1992年 / 61卷 / 02期

关键词：

D O I：

10.1016/0165-4608(92)90078-M

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We report the results of cytogenetic studies of direct bone marrow (BM) preparations and of short-term BM and peripheral blood (PB) cultures from 17 patients with Waldenstrom's macroglobulinemia. We noted clonal chromosome changes in 10 patients. Abnormalities affected chromosomes X, Y, 2, 4, 5, 15, 16, 18, 19, 20, 21, and 22; in particular, chromosomes 2, 4, and 5 were involved in structural changes: a homogeneously staining region [hsr(2)], a der(4)t(4;?)(q32;?), and a 5q+. The other chromosomes were involved in numerical abnormalities, such as pseudodiploidy (a 46,X,-X, +15 clone), loss of chromosome Y, and monosomy of chromosomes 16, 18, 19, 20, 21, and 22. Nonclonal chromosome rearrangements were also observed. The results are discussed in comparison with the few data reported in the literature, and the finding of an hsr in the long arm of chromosome 2 is emphasized; indeed, this is the first report of hsr in WM.

引用

页码：147 / 151

页数：5

共 21 条

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