EFFECTS OF N-METHYL-D-ASPARTATE ON QUISQUALATE-STIMULATED PHOSPHOINOSITIDE HYDROLYSIS IN SLICES OF KITTEN STRIATE CORTEX

被引：8

作者：

BOHNER, AP ^{[1
]}

DUDEK, SM ^{[1
]}

BEAR, MF ^{[1
]}

机构：

[1] BROWN UNIV,DEPT NEUROSCI,POB 1953,PROVIDENCE,RI 02912

来源：

BRAIN RESEARCH | 1992年 / 594卷 / 01期

关键词：

CRITICAL PERIOD; PLASTICITY; EXCITATORY AMINO ACID; METABOTROPIC GLUTAMATE RECEPTOR;

D O I：

10.1016/0006-8993(92)91040-L

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Stimulation of phosphoinositide (PI) hydrolysis by excitatory amino acids (EAAs) was studied in coronal slices of kitten visual cortex. Coincubation with N-methyl-D-aspartate (NMDA) markedly reduced the stimulation by quisqualate, however, this inhibition developed with a latency of > 10 min and occurred even when the NMDA exposure preceded, but did not overlap with, incubation in quisqualate. This time-course of NMDA inhibition of EAA-stimulated PI turnover places new constraints on its possible mechanism of inhibition.

引用

页码：146 / 149

页数：4

共 24 条

[1] LONG-TERM POTENTIATION AND NMDA RECEPTORS IN RAT VISUAL-CORTEX [J].