EFFECT OF DIETARY BUTYLATED HYDROXYTOLUENE ON NUCLEAR-ENVELOPE CYTOCHROME-P-450 DURING THE INITIATION AND PROMOTION STAGES OF HEPATOCARCINOGENESIS

被引：3

作者：

CARUBELLI, R

GRAHAM, SA

MCCAY, PB

机构：

[1] Molecular Toxicology Research Program, Oklahoma Medical Research Foundation

来源：

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL | 1992年 / 18卷 / 01期

关键词：

D O I：

10.1080/01635589209514205

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The anticarcinogenic effect of the dietary antioxidant butylated hydroxytoluene (BHT) correlates with a preservation of nuclear envelope (NE) cytochrome P-450 in rats undergoing chemically induced hepatocarcinogenesis. This effect of BHT on NE cytochrome P-450 was observed during both the initiation and the promotion stages of hepatocarcinogenesis. Complex interactions between the two different mechanisms of action of BHT (i.e., enzyme induction and antioxidant activity) may account for some of the differences between the patterns of response to BHT observed during initiation and promotion.

引用

页码：59 / 62

页数：4

共 13 条

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