THE ANTICOLLAGENOLYTIC POTENTIAL OF LYMECYCLINE IN THE LONG-TERM TREATMENT OF REACTIVE ARTHRITIS

被引：62

作者：

LAUHIO, A

SORSA, T

LINDY, O

SUOMALAINEN, K

SAARI, H

GOLUB, LM

KONTTINEN, YT

机构：

[1] UNIV HELSINKI,DEPT MED CHEM,SF-00100 HELSINKI 10,FINLAND

[2] UNIV HELSINKI,DEPT BACTERIOL,SF-00100 HELSINKI 10,FINLAND

[3] UNIV HELSINKI,DEPT IMMUNOL,SF-00100 HELSINKI 10,FINLAND

[4] UNIV HELSINKI,GEN HOSP,DEPT 4,SF-00100 HELSINKI 10,FINLAND

[5] SUNY STONY BROOK,DEPT ORAL BIOL & PATHOL,STONY BROOK,NY 11794

[6] NYU,HOSP JOINT DIS,INST MOLEC IMMUNOL,NEW YORK,NY 10003

[7] UNIV HELSINKI,DEPT PERIODONT,MANNERHEIMINTIE 172,SF-00300 HELSINKI,FINLAND

来源：

ARTHRITIS AND RHEUMATISM | 1992年 / 35卷 / 02期

关键词：

D O I：

10.1002/art.1780350211

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective. We sought to determine the antiinflammatory properties of lymecycline in the long-term treatment of reactive arthritis (ReA). Methods. Quantitative assay of collagenase activity by densitometry after sodium dodecyl sulfatepolyacrylamide gel electrophoresis. Results. Therapeutic levels of lymecycline do not directly inhibit the activity of human neutrophil interstitial collagenase, but can prevent the oxidative activation of latent human neutrophil collagenase. Conclusion. This non-antimicrobial, anticollagenolytic property of lymecycline may contribute to its therapeutic efficacy in the treatment of patients with ReA.

引用

页码：195 / 198

页数：4

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