EXTRACTIVE SPECTROPHOTOMETRIC DETERMINATION OF AMPHETAMINE IN URINE SAMPLES WITH SODIUM 1,2-NAPHTHOQUINONE 4-SULFONATE

被引：21

作者：

LEGUA, CM ^{[1
]}

FALCO, PC ^{[1
]}

CABEZA, AS ^{[1
]}

机构：

[1] UNIV VALENCIA,DEPT QUIM ANALIT,BURJASSOT,SPAIN

来源：

ANALYTICA CHIMICA ACTA | 1993年 / 283卷 / 01期

关键词：

UV VISIBLE SPECTROPHOTOMETRY; AMPHETAMINE; EXTRACTION; URINE;

D O I：

10.1016/0003-2670(93)85276-P

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Sodium 1,2-naphthoquinone 4-sulphonate (NQS) was tested as a reagent for amphetamine in order to develop an extractive-spectrophotometric method for the determination of the drug in urine samples. The standard additions method showed the absence of proportional bias error whereas the Youden method and the two standard addition plots method showed the presence of a constant bias error [total Youden blank (TYB)]. Acceptable results were obtained by evaluating the TYB error or by using a placebo (urine sample from a normal subject). The dynamic range of concentrations was 1.4-50 mg l-1 in urine samples and the detection limit was 0.6 mg l-1 when 10 ml of urine sample were taken.

引用

页码：635 / 644

页数：10

共 16 条

[1]

AJTAY MK, 1987, REV MED TIRGUMURES, V33, P80

[2] NEW TECHNIQUE IN CHEMICAL-ASSAY CALCULATIONS .1. A SURVEY OF CALCULATIONAL PRACTICES ON A MODEL PROBLEM [J].