INCORPORATION OF 6-THIOGUANOSINE INTO OLIGORIBONUCLEOTIDES

被引：15

作者：

ADAMS, CJ

MURRAY, JB

FARROW, MA

ARNOLD, JRP

STOCKLEY, PG

机构：

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 30期

关键词：

D O I：

10.1016/0040-4039(95)00995-O

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The preparation of N-2-benzoyl-S-6-cyanoethyl-6-thioguanosine and its incorporation into oligoribonucleotides, using standard phosphoramidite methods, is described. 6-Thioguanosine has been incorporated into the three guanosine sites of the central core of the hammerhead ribozyme resulting in 2- to 9-fold reductions in catalytic activity.

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页码：5421 / 5424

页数：4

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