REGULATION OF THE ADRENOMEDULLARY CATECHOLAMINERGIC SYSTEM AFTER MILD, ACUTE STRESS

被引:21
作者
BETITO, K
MITCHELL, JB
BHATNAGAR, S
BOKSA, P
MEANEY, MJ
机构
[1] MCGILL UNIV,DOUGLAS HOSP,RES CTR,DEPT PHARMACOL & THERAPEUT,MONTREAL H4H 1R3,PQ,CANADA
[2] MCGILL UNIV,DOUGLAS HOSP,RES CTR,DEPT PSYCHIAT,MONTREAL H4H 1R3,PQ,CANADA
[3] MCGILL UNIV,DOUGLAS HOSP,RES CTR,DEPT NEUROL & NEUROSURG,MONTREAL H4H 1R3,PQ,CANADA
[4] BOSTON COLL,DEPT PSYCHOL,CHESTNUT HILL,MA 02167
来源
AMERICAN JOURNAL OF PHYSIOLOGY | 1994年 / 267卷 / 01期
关键词
PHENYLETHANOLAMINE N-METHYLTRANSFERASE; TYROSINE HYDROXYLASE; ADRENAL MEDULLA;
D O I
10.1152/ajpregu.1994.267.1.R212
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
The time course of regulation of rat adrenomedullary phenylethanolamine N-methyltransferase (PNMT) and tyrosine hydroxylase (TH) activity was studied after a single episode of 20-min restraint stress. Significant increases in PNMT and TH activity were observed 18 h after the beginning of the stress. The time course of acute stress-induced regulation of PNMT and TH was examined for the influence of neural and hormonal input. Unilateral denervation was performed, and the animals were exposed to a single episode of restraint. PNMT activity increased similarly in both the innervated and denervated adrenals, with a significant increase observed at 36 h after the stress. TH activity was similar in both denervated and innervated adrenals, with a significant increase observed at 24 and 36 h after stress. Finally, suppression of endogenous corticosterone with dexamethasone delayed the stress-induced increase in activity of PNMT but not TH. The present study indicates that increases in catecholamine biosynthetic enzymes can be observed after a single episode of mild, acute stress. In addition, glucocorticoids appear to be important in the time course of the stress-induced increase in PNMT but not TH activity, whereas neural input does not seem to affect the time course of these increases.
引用
收藏
页码:R212 / R220
页数:9
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