AN EFFICIENT SYNTHESIS OF A CHIRAL CARBOCYCLIC 2'-DEOXYRIBONUCLEOSIDE SYNTHON BY DIRECTED REDUCTION

被引：16

作者：

BORTHWICK, AD

CRAME, AJ

EXALL, AM

WEINGARTEN, GG

机构：

[1] Department of Medicinal Chemistry II, Glaxo Research and Development Ltd, Greenford

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 41期

关键词：

D O I：

10.1016/S0040-4039(00)78373-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Directed reduction of the 1,4 hydroxy-ketone 9 and the 1,4 aldehydo-ketone 12 with NaBH(OAc)(3) gave stereoselectively in high yield the 1,4 diol 10, a key intermediate required in our synthesis of chiral carbocyclic 2'-deoxyribonucleosides.

引用

页码：7677 / 7680

页数：4

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