EFFECTS OF A DIAZEPAM-FENTANYL MIXTURE ON CEREBRAL BLOOD-FLOW AND OXYGEN-CONSUMPTION IN MAN

被引：29

作者：

VERNHIET, J ^{[1
]}

RENOU, AM ^{[1
]}

ORGOGOZO, JM ^{[1
]}

CONSTANT, P ^{[1
]}

CAILIE, JM ^{[1
]}

机构：

[1] CTR JEAN ABADIE,SERV NEUROL,89 RUE DES SABLIERES,F-33000 BORDEAUX,FRANCE

来源：

BRITISH JOURNAL OF ANAESTHESIA | 1978年 / 50卷 / 02期

关键词：

D O I：

10.1093/bja/50.2.165

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

The effects of a mixture of diazepam and fentanyl on cerebral blood flow (c.b.f.) and cerebral metabolism of oxygen (CMRo2) were studied in eight normal subjects and 13 patients with organic brain disease. The coupling of flow and metabolism and the carbon dioxide responsiveness of the c.b.f. were studied also. In the normal subjects the injection of the mixture resulted in a significant decrease in c.b.f. (34%), and a similar decrease in CMRo2 (34.5%). The vasoreactivity of the brain to carbon dioxide was maintained. C.b.f. decreased in all patients with intracranial pathology. © 1978 Macmillan Journals Ltd.

引用

页码：165 / 169

页数：5

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