METABOLISM TURNOVER TIME HALF LIFE BODY POOL OF CARNITINE-14C IN NORMAL ALLOXAN DIABETIC AND INSULIN TREATED RATS

被引：41

作者：

MEHLMAN, MA

KADER, MMA

THERRIAULT, DG

机构：

[1] Biochemistry Laboratory, Dept. of Zoology and Physiology, Newark College of Arts and Sciences, Newark, NJ

[2] Dept. of Nutrition and Food Science, Massachusetts Institute of Technology, Natick, MA

[3] U.S. Army Research Institute of Environmental Medicine, Natick, MA

来源：

LIFE SCIENCES PART 1 PHYSIOLOGY AND PHARMACOLOGY AND PART 2 BIOCHEMISTRY GENERAL AND MOLECULAR BIOLOGY | 1969年 / 8卷 / 10P2期

关键词：

D O I：

10.1016/0024-3205(69)90243-4

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The body pool, half-life, turnover-time and carnitine content in muscle were determined in normal, altoxan-diabetic and alloxan-diabetic, insulin treated rats. The carnitine body pool and carnitine muscle content were greatly decreased in alloxan-diabetic rats, whereas the body pool and muscle carnitine content in insulin-treated alloxan-diabetic rats approached a value close to that of normal rats. The decrease in the carnitine body pool of alloxan diabetic rats was accompanied by an increase in the conversion of carnitine to β-methylcholine. The half-life and turnover time were also decreased in diabetic rats. The results indicated that the lowered body pool of carnitine in alloxan-diabetic rats is primarily due to a decrease in the turnover time and increase in metabolism of carnitine. © 1969.

引用

页码：465 / +

页数：1

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