SUBCELLULAR LOCALIZATION OF PTEROYL POLYGLUTAMATE HYDROLASE AND FOLATE IN GUINEA PIG INTESTINAL MUCOSA

被引：84

作者：

HOFFBRAN.AV

PETERS, TJ

机构：

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1969年 / 192卷 / 03期

关键词：

D O I：

10.1016/0304-4165(69)90397-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

1. 1. Guinea pig intestinal mucosa was fractionated by two methods and the subcellular localization of pteroyl polyglutamate hydrolase (formerly known as folate conjugase) was determined. 2. 2. Pteroyl polyglutamate hydrolase appeared to be localized predominantly in the lysosomal fraction: no significant brush-border localization of the enzyme was noted. 3. 3. Folate was concentrated in the mitochondrial fraction. 4. 4. Possible mechanisms of pteroyl polyglutamate absorption are discussed in the light of the findings. © 1969.

引用

页码：479 / &

共 42 条

[1] BAKER H, 1965, AM J CLIN NUTR, V17, P88, DOI 10.1093/ajcn/17.2.88
[2] BIRD OD, 1946, J BIOL CHEM, V163, P649
[3] STUDIES OF INTESTINAL DIGESTION AND ABSORPTION IN THE HUMAN
BORGSTROM, B
DAHLQVIST, A
LUNDH, G
SJOVALL, J
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1957, 36 (10) : 1521 - 1536
[4] ABSORPTION OF FOLIC ACID FROM SMALL INTESTINE OF RAT
BURGEN, ASV
GOLDBERG, NJ
[J]. BRITISH JOURNAL OF PHARMACOLOGY AND CHEMOTHERAPY, 1962, 19 (02): : 313 - &
[5] PTEROYLGLUTAMATE COMPONENTS OF AMERICAN DIETS AS DETERMINED BY CHROMATOGRAPHIC FRACTIONATION
BUTTERWORTH, CE
FROMMEYER, WB
SANTINI, R
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1963, 42 (12) : 1929 - &
[6] THE ACTIVITY OF DIGESTION ENZYMES ON PTEROYLGLUTAMIC ACID (FOLIC ACID) AND PTEROYL-HEXA-GLUTAMYL-GLUTAMIC ACID (FOLIC ACID CONJUGATE)
BUYZE, HG
ENGEL, C
[J]. BIOCHIMICA ET BIOPHYSICA ACTA, 1948, 2 (02) : 217 - 222
[7] THE INGESTION OF PROTEINS AND COLLOIDAL MATERIALS BY COLUMNAR ABSORPTIVE CELLS OF THE SMALL INTESTINE IN SUCKLING RATS AND MICE
CLARK, SL
[J]. JOURNAL OF BIOPHYSICAL AND BIOCHEMICAL CYTOLOGY, 1959, 5 (01): : 41 - +
[8] COOPERSTEIN SJ, 1951, J BIOL CHEM, V189, P665
[9] DIGESTIVE-ABSORPTIVE SURFACE OF SMALL BOWEL MUCOSA
CRANE, RK
[J]. ANNUAL REVIEW OF MEDICINE, 1968, 19 : 57 - +
[10] FUNCTIONS OF LYSOSOMES
DEDUVE, C
WATTIAUX, R
[J]. ANNUAL REVIEW OF PHYSIOLOGY, 1966, 28 : 435 - +

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