STEROID-RECEPTORS IN EXOCRINE GLANDS - PANCREAS AND PROSTATE

被引:56
作者
SANDBERG, AA
ROSENTHAL, HE
机构
[1] Roswell Park Memorial Institute, Buffalo
关键词
D O I
10.1016/0022-4731(79)90311-X
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The exocrine pancreas and prostate, though embryologically related, are subject to different control mechanisms, with only the latter gland being profoundly influenced by testicular and/or hypophyseal secretions. However, oestrogen and androgen receptors have been demonstrated in the pancreatic acinar cells (human, rat, guinea pig and baboon), with a high affinity, low capacity receptor for oestradiol (E2) being overshadowed quantitatively by a high capacity oestrogen-binding protein (EBP) primarily associated with the microsomal fraction. Immunologie and chemico-physical studies have pointed to the cellular specificity of the EBP. In the prostate, androgen and oestrogen receptors and their specificity and uniqueness have been established in a number of species (human, baboon, rat). Of particular importance is the relation of plasma TeBG (sex-hormone binding globulin) to these receptors, because of the high affinity of TeBG for the steroids. Studies and interpretations related to these parameters are presented. © 1979.
引用
收藏
页码:293 / 299
页数:7
相关论文
共 25 条