INTEGRATION OF COMPUTER-AIDED METHOD DEVELOPMENT TECHNIQUES IN LC

Computer-aided method development techniques have been commercially available for a number of years. Each of these procedures has strengths and weaknesses. In the past, hidden difficulties in the practical application of computer-aided method development have discouraged their widespread use. This paper proposes the complementary use of these techniques so that their strengths are maximized while their weaknesses are compensated for. The result is a method development strategy that obtains simple solutions for simple separation problems and reserves the more complex solutions for difficult separations.