HYPOLIPIDEMIC ACTIVITY OF PHTHALIMIDE DERIVATIVES .1. N-SUBSTITUTED PHTHALIMIDE DERIVATIVES

被引：59

作者：

CHAPMAN, JM ^{[1
]}

COCOLAS, GH ^{[1
]}

HALL, IH ^{[1
]}

机构：

[1] UNIV N CAROLINA,DIV MED CHEM,CHAPEL HILL,NC 27514

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1979年 / 22卷 / 11期

关键词：

D O I：

10.1021/jm00197a022

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The general lipid-lowering action of the N-substituted phthalimide derivatives reported herein, as well as the activity of potassium phthalimide, implicates the phthalimide moiety as possessing hypolipidemic activity in rodents. Compounds containing substituents with chain lengths of four carbon or oxygen atoms showed the best hypolipidemic activity in the series tested. Tests involving l-AT-phthalimidobutan-3-one demonstrated a dose-dependent hypolipidemic action free of estrogenic side effects, with no apparent deposition of cholesterol in body organs, and with a high therapeutic index. Further work on the hypolipidemic activity of phthalimido, as well as other imido compounds, is underway. © 1979, American Chemical Society. All rights reserved.

引用

页码：1399 / 1402

页数：4

共 37 条

[1] INHIBITORS OF POLYAMINE BIOSYNTHESIS .1. ALPHA-METHYL-(+/-)-ORNITHINE, AN INHIBITOR OF ORNITHINE DECARBOXYLASE [J].