EFFECTS OF 5-BROMO-2-DEOXYURIDINE AND 2-DEOXY-D-GLUCOSE ON RADIATION-INDUCED MICRONUCLEI IN MOUSE BONE-MARROW

被引：31

作者：

SINGH, SP ^{[1
]}

SINGH, S ^{[1
]}

JAIN, V ^{[1
]}

机构：

[1] INST NUCL MED & ALLIED SCI,DELHI 110054,INDIA

来源：

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY | 1990年 / 58卷 / 05期

关键词：

D O I：

10.1080/09553009014552171

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Effects of 2-deoxy-d-glucose (2-DG) and 5-bromo-2-deoxyuridine (BrdU) on 60Co γradiation-induced damage in normal mouse bone marrow have been investigated. Cytogenetic damage as measured by the frequency of cells with micronuclei was studied at various time intervals after irradition. Intravenous administration of 2-DG (0.1 ml, 1 g/kg body weight) just before or after whole-body irradiation (absorbed dose 2.5 Gy) significantly reduced the micronuclei fraction as compared with irradiated controls. Incorporation of BrdU given intraperitoneally in 13 injections (0.3 ml) (total dose 2 g/kg body weight) at intervals of 1 h increased the micronuclei frequency, but administration of 2-DG significantly decreased cytogenetic damage. The results have interesting implications for improving tumour radiotherapy. © 1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：791 / 797

页数：7

共 30 条

[1] PRODUCTION OF MICRONUCLEI FROM CHROMOSOME-ABERRATIONS IN IRRADIATED CULTURES OF HUMAN LYMPHOCYTES [J].