MOLECULAR-CLONING OF CDNA FOR THE HUMAN TUMOR-ASSOCIATED ANTIGEN CO-029 AND IDENTIFICATION OF RELATED TRANSMEMBRANE ANTIGENS

被引：146

作者：

SZALA, S ^{[1
]}

KASAI, Y ^{[1
]}

STEPLEWSKI, Z ^{[1
]}

RODECK, U ^{[1
]}

KOPROWSKI, H ^{[1
]}

LINNENBACH, AJ ^{[1
]}

机构：

[1] WISTAR INST,3601 SPRUCE ST,PHILADELPHIA,PA 19104

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1990年 / 87卷 / 17期

关键词：

CD37; Cos cell expression; ME491; Sm23;

D O I：

10.1073/pnas.87.17.6833

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The human tumor-associated antigen CO-029 is a monoclonal antibody-defined cell surface glycoprotein of 27-34 kDa. By using the high-efficiency COS cell expression system, a full-length cDNA clone for CO-029 was isolated. When transiently expressed in COS cells, the cDNA clone directed the synthesis of an antigen reactive to monoclonal antibody CO-029 in mixed hemadsorption and immunoblot assays. Sequence analysis revealed that CO-029 belongs to a family of cell surface antigens that includes the melanoma-associated antigen ME491, the leukocyte cell surface antigen CD37, and the Sm23 antigen of the parasitic helminth Schistosoma mansoni. CO-029 and ME491 antigen expression and the effect of their corresponding monoclonal antibodies on cell growth were compared in human tumor cell lines of various histologic origins.

引用

页码：6833 / 6837

页数：5

共 35 条

[1] INHIBITION OF INTRACTABLE NUCLEASES WITH RIBONUCLEOSIDE-VANADYL COMPLEXES - ISOLATION OF MESSENGER RIBONUCLEIC-ACID FROM RESTING LYMPHOCYTES
BERGER, SL
BIRKENMEIER, CS
[J]. BIOCHEMISTRY, 1979, 18 (23) : 5143 - 5149
[2] THE PRIMARY STRUCTURE OF THE HUMAN-LEUKOCYTE ANTIGEN CD37, A SPECIES HOMOLOG OF THE RAT MRC OX-44 ANTIGEN
CLASSON, BJ
WILLIAMS, AF
WILLIS, AC
SEED, B
STAMENKOVIC, I
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1989, 169 (04) : 1497 - 1502
[3] DAYHOFF MO, 1983, METHOD ENZYMOL, V91, P524
[4] A COMPREHENSIVE SET OF SEQUENCE-ANALYSIS PROGRAMS FOR THE VAX
DEVEREUX, J
HAEBERLI, P
SMITHIES, O
[J]. NUCLEIC ACIDS RESEARCH, 1984, 12 (01) : 387 - 395
[5] MOLECULAR-CLONING AND NUCLEOTIDE-SEQUENCE OF A FULL-LENGTH CDNA FOR HUMAN ALPHA-ENOLASE
GIALLONGO, A
FEO, S
MOORE, R
CROCE, CM
SHOWE, LC
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (18) : 6741 - 6745
[6] GIRARDET C, 1986, J IMMUNOL, V136, P1497
[7] GOTTLINGER HG, 1986, INT J CANCER, V38, P47
[8] EFFICIENT SELECTION OF HUMAN-TUMOR GROWTH-INHIBITING MONOCLONAL-ANTIBODIES
HERLYN, D
HERLYN, M
ROSS, AH
ERNST, C
ATKINSON, B
KOPROWSKI, H
[J]. JOURNAL OF IMMUNOLOGICAL METHODS, 1984, 73 (01) : 157 - 167
[9] HERLYN M, 1986, HYBRIDOMA, V5, pS3
[10] HERLYN M, 1980, CANCER RES, V40, P3602

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