RELATIVE PREVALENCE AND RISK-FACTORS OF HTLV-I AND HTLV-II INFECTION IN UNITED-STATES BLOOD-DONORS

被引:112
作者
LEE, HH
SWANSON, P
ROSENBLATT, JD
CHEN, ISY
SHERWOOD, WC
SMITH, DE
TEGTMEIER, GE
FERNANDO, LP
FANG, CT
OSAME, M
KLEINMAN, SH
机构
[1] JONSSON COMPREHENS CANC CTR,DEPT MED,LOS ANGELES,CA
[2] UNIV CALIF LOS ANGELES,SCH MED,LOS ANGELES,CA 90024
[3] AMER RED CROSS,PENN JERSEY REG BLOOD SERV,PHILADELPHIA,PA
[4] SE LOUISIANA INC,CTR BLOOD,NEW ORLEANS,LA
[5] COMMUNITY BLOOD CTR GREATER KANSAS CITY,KANSAS CITY,KS
[6] SACRAMENTO MED FDN,CTR BLOOD,SACRAMENTO,CA
[7] AMER RED CROSS,JEROME H HOLLAND LAB,ROCKVILLE,MD
[8] KAGOSHIMA UNIV,SCH MED,DEPT INTERNAL MED 3,KAGOSHIMA 890,JAPAN
[9] AMER RED CROSS,LOS ANGELES CTY REG BLOOD SERV,LOS ANGELES,CA
[10] AMER RED CROSS,ORANGE CTY REG BLOOD SERV,LOS ANGELES,CA
关键词
D O I
10.1016/0140-6736(91)93126-T
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The clinical significance of human T-cell lymphotropic virus type II (HTLV-II) infection, unlike that of HTLV-I, is unknown, and the major known association of HTLV-II seropositivity is with intravenous drug abuse. Screening of blood donors for HTLV-I, now routine in North America, does not distinguish this retrovirus from HTLV-II. To find out more about the seroepidemiology of and risk factors for HTLV I and II, blood from 480 000 volunteer donors in five geographically separate US urban centres was tested for antibodies to HTLV-I/II and HIV-1. Confirmed HTLV-I/II seropositive donors were then followed up by DNA amplification to distinguish type I from type II and by interviews focusing on possible risk factors. HTLV seroprevalence was 3.3 times greater than that for HIV-1 (0.043% vs 0.013%). DNA amplification on 65 of the 207 HTLV-I/II seropositive donors revealed that 34 (52%) had HTLV-II infection and 28 (43% had HTLV-I; 3 samples were uninformative. Interviews of 49 donors showed that whereas HTLV-I was principally associated with donor origin from endemic regions, the major risk factor for HTLV-II infection was intravenous drug use. The surprisingly high rate of HTLV-II infection in US blood donors raises important public health and donor counselling issues since HTLV-I infection is associated with adult T-cell leukaemia and a neurological disorder while the pathogenicity of HTLV-II is as yet unclear.
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收藏
页码:1435 / 1439
页数:5
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