THE ROLE OF C-MYC IN CELL-GROWTH

被引：373

作者：

EVAN, GI ^{[1
]}

LITTLEWOOD, TD ^{[1
]}

机构：

[1] IMPERIAL CANC RES FUND, LONDON WC2A 3PX, ENGLAND

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 1993年 / 3卷 / 01期

关键词：

D O I：

10.1016/S0959-437X(05)80339-9

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Recent experiments have established that the c-myc oncogene encodes a sequence-specific DNA-binding protein that interacts with a specific intracellular partner, Max, and probably manifests its effects through transcriptional modulation. In addition, the range of biological functions attributed to expression of c-myc has grown to include not only transformation and mitogenesis but also cell death.

引用

页码：44 / 49

页数：6

共 68 条

[1] TRANSGENIC MODELS FOR HEMATOPOIETIC MALIGNANCIES
ADAMS, JM
CORY, S
[J]. BIOCHIMICA ET BIOPHYSICA ACTA, 1991, 1072 (01) : 9 - 31
[2] ALNEMRI ES, 1992, CANCER RES, V52, P491
[3] TRANSCRIPTIONAL ACTIVATION BY THE HUMAN C-MYC ONCOPROTEIN IN YEAST REQUIRES INTERACTION WITH MAX
AMATI, B
DALTON, S
BROOKS, MW
LITTLEWOOD, TD
EVAN, GI
LAND, H
[J]. NATURE, 1992, 359 (6394) : 423 - 426
[4] ASKEW DS, 1991, ONCOGENE, V6, P1915
[5] BERBERICH S, 1992, ONCOGENE, V7, P775
[6] CASEIN KINASE-II INHIBITS THE DNA-BINDING ACTIVITY OF MAX HOMODIMERS BUT NOT MYC MAX HETERODIMERS
BERBERICH, SJ
COLE, MD
[J]. GENES & DEVELOPMENT, 1992, 6 (02) : 166 - 176
[7] TUMORIGENESIS IN TRANSGENIC MICE - IDENTIFICATION AND CHARACTERIZATION OF SYNERGIZING ONCOGENES
BERNS, A
[J]. JOURNAL OF CELLULAR BIOCHEMISTRY, 1991, 47 (02) : 130 - 135
[8] APOPTOTIC CELL-DEATH INDUCED BY C-MYC IS INHIBITED BY BCL-2
BISSONNETTE, RP
ECHEVERRI, F
MAHBOUBI, A
GREEN, DR
[J]. NATURE, 1992, 359 (6395) : 552 - 554
[9] SEQUENCE-SPECIFIC DNA-BINDING BY THE C-MYC PROTEIN
BLACKWELL, TK
KRETZNER, L
BLACKWOOD, EM
EISENMAN, RN
WEINTRAUB, H
[J]. SCIENCE, 1990, 250 (4984) : 1149 - 1151
[10] MYC AND MAX ASSOCIATE INVIVO
BLACKWOOD, EM
LUSCHER, B
EISENMAN, RN
[J]. GENES & DEVELOPMENT, 1992, 6 (01) : 71 - 80

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