NO EVIDENCE FOR THE EXISTENCE OF PREFORMED ANTIBODIES AGAINST HYDROXYETHYL STARCH IN MAN

被引：18

作者：

KRAFT, D

SIRTL, C

LAUBENTHAL, H

SCHEINER, O

PARTH, E

DIETERICH, HJ

SZEPFALUSI, Z

TRAMPISCH, HJ

GERLACH, E

PETER, K

机构：

[1] RUHR UNIV BOCHUM,DEPT MED STAT,W-4630 BOCHUM,GERMANY

[2] UNIV MUNICH,DEPT PHYSIOL,W-8000 MUNICH 2,GERMANY

[3] ST JOSEF HOSP,ANAESTHESIOL CLIN,BOCHUM,GERMANY

[4] INST ANAESTHESIOL,MUNICH,GERMANY

来源：

EUROPEAN SURGICAL RESEARCH | 1992年 / 24卷 / 03期

关键词：

HYDROXYETHYL STARCH; COLLOID SOLUTIONS; ANAPHYLACTOID REACTIONS; ENZYME-LINKED IMMUNOSORBENT ASSAY; HYDROXYETHYL STARCH-REACTIVE ANTIBODIES;

D O I：

10.1159/000129200

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Using the highly sensitive ELISA technique for detecting anti-hydroxyethyl starch (HES) antibodies in man sera from 1,056 patients were analyzed. Patients of both sex, who had never had any prior contact with HES, were included in the study. In none of the cases could any titer of HES-reactive antibodies be detected. These data suggest that in man preformed HES-reactive antibodies do not exist or are extremely rare. In any case, unlike dextran-reactive antibodies, they should not have a high clinical importance. The mechanism behind the very rarely observed anaphylactoid reactions after HES application is still unknown.

引用

页码：138 / 142

页数：5

共 30 条

[1] ADELMANNGRILL BC, 1981, DEV BIOL STAND, V48, P235
[2] AHNEFELD FW, 1979, ANAESTHESIST, V28, P207
[3] ANTIGENICITY OF HYDROXYETHEL STARCH IN HUMANS - STUDIES IN 7 NORMAL VOLUNTEERS
BRICKMAN, RD
MURRAY, GF
THOMPSON, WL
BALLINGER, WF
[J]. JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1966, 198 (12) : 1277 - +
[4] SEVERE ANAPHYLACTOID REACTION TO HYDROXYETHYL STARCH
CULLEN, MJ
SINGER, M
[J]. ANAESTHESIA, 1990, 45 (12) : 1041 - 1042
[5] INCIDENCES OF FATAL POSTOPERATIVE PULMONARY-EMBOLISM AFTER PROPHYLAXIS WITH DEXTRAN 70 AND LOW-DOSE HEPARIN - INTERNATIONAL MULTICENTER STUDY
GRUBER, UF
SALDEEN, T
BROKOP, T
EKLOF, B
ERIKSSON, I
GOLDIE, I
GRAN, L
HOHL, M
JONSSON, T
KRISTERSSON, S
LJUNGSTROM, KG
LUND, T
MAARTMANMOE, H
SVENSJO, E
THOMSON, D
TORHORST, J
TRIPPESTAD, A
ULSTEIN, M
[J]. BRITISH MEDICAL JOURNAL, 1980, 280 (6207) : 69 - 72
[6] DEXTRAN-INDUCED ANAPHYLACTOID REACTIONS IN MAN - ROLE OF DEXTRAN REACTIVE ANTIBODIES
HEDIN, H
RICHTER, W
RING, J
[J]. INTERNATIONAL ARCHIVES OF ALLERGY AND APPLIED IMMUNOLOGY, 1976, 52 (1-4): : 145 - 159
[7] HEDIN H, 1982, INT ARCH ALLER A IMM, V68, P122, DOI 10.1159/000233080
[8] HEDIN H, 1981, DEV BIOL STAND, V48, P179
[9] HEDIN H, 1979, IMMUNOBIOLOGY, V166, P289
[10] HEDIN H, 1977, ACTA U UPSAL, V432, P1

← 1 2 3 →