SUPPRESSIVE EFFECT OF THE DOPAMINE D2-RECEPTOR AGONIST B-HT 920 ON RAT GROOMING

被引：10

作者：

FERRARI, F ^{[1
]}

PELLONI, F ^{[1
]}

GIULIANI, D ^{[1
]}

机构：

[1] UNIV MODENA,INST PHARMACOL,VIA G CAMPI 287,I-41100 MODENA,ITALY

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1992年 / 216卷 / 03期

关键词：

GROOMING BEHAVIOR; B-HT; 920; ADRENOCORTICOTROPIN HORMONE; DOPAMINE D2-RECEPTORS; STRETCHING AND YAWNING; SHAKES;

D O I：

10.1016/0014-2999(92)90429-8

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effect of the D2 agonist B-HT 920 was examined on three behavioural models of induced grooming in the rat. B-HT 920 potently inhibited the grooming elicited by a novel environment, whereas it stimulated the stretching-yawning syndrome. Pretreatment with the selective dopamine D2 receptor antagonist, sulpiride, reversed the phenomenon. When B-HT 920 was administered to rats before water immersion, it similarly antagonized total grooming; wet-dog shakes, detected in these same animals, were potently inhibited. Finally, B-HT 920 displayed inhibitory activity towards adrenocorticotropin hormone-induced excessive rooming. On the basis of these effects, the role of D2 receptor subtypes in the modulation of grooming is discussed.

引用

页码：345 / 350

页数：6

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