CORRELATION OF INTERLEUKIN-2 AND SOLUBLE INTERLEUKIN-2 RECEPTOR WITH CLINICAL ACTIVITY OF MULTIPLE-SCLEROSIS

被引:46
作者
SHARIEF, MK
THOMPSON, EJ
机构
[1] Dep Clinical Neurochemistry, Institute of Neurology, National Hosp Neurol Neurosurgery, London WC1N 3BG, Queen Square
关键词
D O I
10.1136/jnnp.56.2.169
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Concentrations of interleukin-2 (IL-2) and soluble IL-2 receptor (sIL-2R) in serum and CSF samples were measured in 63 patients with multiple sclerosis (MS) to evaluate their usefulness as markers of disease activity. CSF concentrations of IL2 and sIL-2R were significantly higher in MS relapse compared with MS patients in remission or with control subjects. These concentrations correlated with the clinical score by which disease severity was assessed, with the number of relapses per year, and with the total disease duration. Furthermore, there was evidence of intrathecal release of IL-2 and sIL-2R in clinically active MS. The results extend the notion that an activated cellular immune state parallels the evolution of the pathological process in MS and suggest that measurement of IL-2 and sIL-2R concentrations may provide an objective marker of disease activity in patients with MS
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页码:169 / 174
页数:6
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