CHEMOPREVENTION OF CHEMICALLY-INDUCED SKIN TUMOR-DEVELOPMENT BY DIALLYL SULFIDE AND DIALLYL DISULFIDE

被引：48

作者：

DWIVEDI, C ^{[1
]}

ROHLFS, S ^{[1
]}

JARVIS, D ^{[1
]}

ENGINEER, FN ^{[1
]}

机构：

[1] S DAKOTA STATE UNIV,COLL PHARM,BROOKINGS,SD 57007

来源：

PHARMACEUTICAL RESEARCH | 1992年 / 9卷 / 12期

关键词：

CHEMOPREVENTION; GARLIC; DIALLYL SULFIDE; DIALLYL DISULFIDE;

D O I：

10.1023/A:1015845315500

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Garlic and onion oil have been shown to inhibit chemically induced skin tumor development in mice. In the present study, the effects of diallyl sulfide and diallyl disulfide, oil-soluble constituents of garlic and onion, on 7,12-dimethylbenz(a)anthracene-induced and 12,O-tetradecanoylphorbol-13-acetate-promoted skin tumor formation were examined in SENCAR mice. Topical application of diallyl sulfide or diallyl disulfide significantly inhibited skin papilloma formation from the ninth week of promotion and significantly increased the rate of survival in the murine model. Our findings support earlier evidence that these naturally occurring compounds may be useful for the chemoprevention of certain types of tumors.

引用

页码：1668 / 1670

页数：3

共 15 条

[1] PUTATIVE METABOLITES DERIVED FROM DIETARY COMBINATIONS OF CALCIUM GLUCARATE AND N-(4-HYDROXYPHENYL)RETINAMIDE ACT SYNERGISTICALLY TO INHIBIT THE INDUCTION OF RAT MAMMARY-TUMORS BY 7,12-DIMETHYLBENZ[A]ANTHRACENE [J].