INFLUENCE OF MATERNAL FACTORS ON CORD AND NEONATAL PLASMA MICRONUTRIENT LEVELS

被引：23

作者：

DISON, PJ ^{[1
]}

LOCKITCH, G ^{[1
]}

HALSTEAD, AC ^{[1
]}

PENDRAY, MR ^{[1
]}

MACNAB, A ^{[1
]}

WITTMANN, BK ^{[1
]}

机构：

[1] BRITISH COLUMBIA CHILDRENS HOSP,DEPT PATHOL,4480 OAK ST,VANCOUVER V6H 3V4,BC,CANADA

来源：

AMERICAN JOURNAL OF PERINATOLOGY | 1993年 / 10卷 / 01期

关键词：

D O I：

10.1055/s-2007-994696

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

The influence of gestational length, maternal prenatal supplement and maternal levels on umbilical cord and neonatal plasma selenium, alpha-tocopherol, and retinol were studied and appropriate reference intervals for ongoing studies of gestational and perinatal micronutrient requirements were derived. We measured retinol, alpha-tocopherol (total and alpha-tocopherol:cholesterol ratio), selenium, and glutathione peroxidase in 160 umbilical cord samples and 58 paired maternal and neonatal samples collected on the third postpartum day. Selenium and glutathione peroxidase were also measured in 25 paired umbilical artery and vein samples. The strongest correlation with gestational age and birthweight was found for the cord blood variables, whereas levels in maternal blood were not related to either gestation or weight. Neonatal values were significantly lower than maternal for selenium (0.96 [0.25] compared with 1.56 [0.27] mumol/liter, retinol (0.54 [0.19] and 1.26 [0.45] mumol/liter, alpha-tocopherol (11.5 [3.63] and 32.4 [9.20] mumol/liter), and glutathione peroxidase (446 [174] and 873 [176] U/liter) but not for the ratio of alpha-tocopherol:cholesterol (5.0 compared with 6.0). Maternal use of tocopherol and retinol supplements did not significantly affect blood concentrations. Maternal plasma selenium levels at term were about 60% of nonpregnant adult females. Selenium concentration and glutathione peroxidase activity did not differ between paired umbilical cord arterial and venous samples. Selenium, retinol, and glutathione peroxidase differed between infants born before or after 37 weeks' gestation.

引用

页码：30 / 35

页数：6

共 38 条

[1]

Hustead V.A., Gutcher G.R., Anderson S.A., Zachman R.D., Relationship of vitamin A (retinol) status to lung disease in the preterm infant, J Pediatr, 105, pp. 610-615, (1984)

[2]

Shah R.S., Rajalakshmi R., Vitamin A status of the newborn in relation to gestational age, body weight, and maternal nutritional status, Am Clin Nulr, 40, pp. 794-800, (1984)

[3]

Shah R.S., Rajalakshmi R., Bhatt R.V., Hazra M.N., Patel B.C., Swamy N.B., Vitamin E status of the newborn in relation to gestational age, birth weight and maternal vitamin E status, Br J Nutr, 58, pp. 191-198, (1987)

[4]

Shenai J.P., Kennedy K.A., Chytil F., Stahlman M.T., Clinicaltrial of vitamin A supplementation in infants susceptible to bronchopulmonary dysplasia, J Pediatr, 111, pp. 269-277, (1987)

[5]

Conway S.P., Rawson I., Dear P.R.F., Shires S.E., Kelleher J., Theearly anaemia of the premature infant: Is there a place for vitamin E supplementation?, Br ) Nutr, 56, pp. 105-114, (1986)

[6]

Johnson I., Quinn G.E., Abbasi S., Et al., Effect of sustainedpharmacologic vitamin E levels on incidence and severity of retinopathy of prematurity: A controlled clinical trial, J Pediatr, 111, pp. 827-838, (1989)

[7]

Sinha S., Davies J., loner N., Bogle S., Chiswick M., Vitamin Esupplementation reduces frequency of periventricular haemorrhage in very preterm babies, Lancet, i, pp. 466-47l, (1987)

[8]

Zipursky A., Brown E.J., Watts J., Milner R., Rand C., Blanchette V.S., Bell F.F., Paes B., Iing F., Oral Vitamin F. supplementation for the prevention of anemia in premature infants: A controlled trial, Pediatrics, 79, pp. 61-68, (1987)

[9]

Lockitch G., Jacobson B.E., Quigley C., Dison P., Pendray M.R., Selenium deficiency in low birthweight neonates: An unrecognized problem, J Pediatr, 114, pp. 865-870, (1989)

[10]

Huston R.K., Shearer T.R., Jelen B.J., YVhall P.D., Reynolds J.W., Relationship of antioxidant enzymes to trace metals in premature infants, J PEN, 11, pp. 163-168, (1987)

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