ONE-SIDED INVASION EVENTS IN HOMOLOGOUS RECOMBINATION AT DOUBLE-STRAND BREAKS

被引：95

作者：

BELMAAZA, A ^{[1
]}

CHARTRAND, P ^{[1
]}

机构：

[1] UNIV MONTREAL, DEPT MICROBIOL & IMMUNOL, MONTREAL, PQ, CANADA

来源：

MUTATION RESEARCH | 1994年 / 314卷 / 03期

基金：

英国医学研究理事会;

关键词：

ONE-SIDED INVASION EVENTS; HOMOLOGOUS RECOMBINATION; DOUBLE-STRAND BREAKS;

D O I：

10.1016/0921-8777(94)90065-5

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Two classes of homologous recombination mechanism for repair of double-strand breaks (DSBs) have been described in eukaryotes so far. One is conservative and has been explained by the double-strand break repair model (Szostak et al., 1983), whereas the other one is non-conservative and has been explained by the single-strand annealing model (Lin et al., 1984). Here, we will review data supporting the existence of another homologous recombination mechanism for double-strand break repair. We will present the one-sided invasion model that we have proposed to explain this mechanism and discuss its potential implication in various homologous recombination events.

引用

页码：199 / 208

页数：10

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