REDUCED INTERFERON-GAMMA SECRETION IN NEONATES AND SUBSEQUENT ATOPY

被引:365
作者
TANG, MLK
KEMP, AS
THORBURN, J
HILL, DJ
机构
[1] ROYAL CHILDRENS HOSP,DEPT IMMUNOL,MELBOURNE,VIC,AUSTRALIA
[2] ROYAL CHILDRENS HOSP,DEPT ALLERGY,MELBOURNE,VIC,AUSTRALIA
[3] MERCY MATERN HOSP,DEPT NEONATAL PEDIAT,MELBOURNE,VIC,AUSTRALIA
关键词
D O I
10.1016/S0140-6736(94)91641-1
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Low interferon-gamma (IFN-gamma) secretion has been found in individuals with active atopic disease. Whether this is a cause or result of the disease process is uncertain. Cord blood IFN-gamma secretion was examined in 35 neonates who were then prospectively followed up for 1 year for the development of atopic disease. Infants who developed either symptoms of atopic disease or a positive IgE-mediated skin prick test at 12 months of age produced significantly less IFN-gamma at birth compared with those who did not (p = 0.005). This reduced secretion of IFN-gamma at birth indicates that the defect in interferon secretion is a primary component of the atopic state rather than an effect of the disease process.
引用
收藏
页码:983 / 985
页数:3
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