MULTIPLE ANTIMICROBIAL RESISTANCE OF PNEUMOCOCCI IN CHILDREN WITH OTITIS-MEDIA, BACTEREMIA, AND MENINGITIS IN SLOVAKIA

被引：50

作者：

REICHLER, MR

RAKOVSKY, J

SOBOTOVA, A

SLACIKOVA, M

HLAVACOVA, B

HILL, B

KRAJCIKOVA, L

TARINA, P

FACKLAM, RR

BREIMAN, RF

机构：

[1] CTR DIS CONTROL & PREVENT, NATL IMMUNIZATION PROGRAM, DIV BACTERIAL & MYCOT DIS, ATLANTA, GA 30333 USA

[2] CTR DIS CONTROL & PREVENT, NATL CTR INFECT DIS, HOSP INFECT PROGRAM, ATLANTA, GA 30333 USA

[3] NATL INST HYG & EPIDEMIOL, BRATISLAVA, SLOVAKIA

来源：

JOURNAL OF INFECTIOUS DISEASES | 1995年 / 171卷 / 06期

关键词：

D O I：

10.1093/infdis/171.6.1491

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Penicillin-resistant pneumococci have been isolated from middle ear fluid, blood, cerebrospinal fluid, and nasopharyngeal secretions of several hundred children in Slovakia since 1985; 116 of these isolates were serotyped and tested for susceptibility to antimicrobial drugs at the Centers for Disease Control and Prevention. To define the prevalence of drug-resistant pneumococci and identify risk factors for infection, laboratory and medical records were reviewed. Nearly all (96%) of the resistant strains tested were serotype 14. Of these, all were resistant to penicillin (MIC, 4-16 mu g/mL); most were resistant to cefaclor, erythromycin, tetracycline, and chloramphenicol; and many had decreased susceptibility to trimethoprim-sulfamethoxazole and ceftriaxone. Frequent antibiotic use, prior hospitalization, and length of hospital stay (P < .001 for all 3) were associated with infection with resistant strains. These findings suggest the need for routine screening of pneumococcal isolates for penicillin resistance and highlight the importance of controlling globally the spread of resistant pneumococci.

引用

页码：1491 / 1496

页数：6

共 42 条

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