PATHOLOGY OF THE UMBILICAL-CORD IN CONGENITAL-SYPHILIS - ANALYSIS OF 25 SPECIMENS USING HISTOCHEMISTRY AND IMMUNOFLUORESCENT ANTIBODY TO TREPONEMA-PALLIDUM

被引：18

作者：

SCHWARTZ, DA

LARSEN, SA

BECKSAGUE, C

FEARS, M

RICE, RJ

机构：

[1] EMORY UNIV,SCH MED,DEPT PATHOL,ATLANTA,GA 30322

[2] CTR DIS CONTROL & PREVENT,NATL CTR INFECT DIS,DIV SEXUALLY TRANSMITTED DIS LAB RES,ATLANTA,GA 30341

来源：

HUMAN PATHOLOGY | 1995年 / 26卷 / 07期

关键词：

CONGENITAL INFECTION; PLACENTA; UMBILICAL CORD; STILLBIRTH; SYPHILIS; TREPONEMA PALLIDUM; IMMUNOFLUORESCENT ANTIBODY;

D O I：

10.1016/0046-8177(95)90228-7

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Identification of Treponema pallidum in the placenta is important for diagnosis of congenital syphilis; however, spirochetes are difficult to observe in chorionic villi. To determine the sensitivity of umbilical cord examination for T pallidum, and the association of spirochetes with cord pathology, placentas were prospectively obtained from 25 women with untreated syphilis. The most common finding using hematoxylin-eosin staining was a normal-appearing umbilical cord (48%); necrotizing funisitis: was the most frequent pathological lesion (36%). Spirochetes were detected using silver and immunofluorescent staining in 89% of cords, including 92% of histologically normal and 84% of abnormal cords. Three specimens showed subamnionic aggregates of spirochetes, consistent with amniotic fluid infection. Necrotizing funisitis was strongly associated with umbilical artery infection spirochetes (P =.008), There was a 100% correlation between results of silver and immunofluorescent staining. The umbilical cord is a sensitive site for morphological confirmation of T pallidum; it is significant for the pathologist that spirochetes may often be detected in the absence of overt tissue inflammation or necrosis. Copyright (C) 1995 by W.B. Saunders Company

引用

页码：784 / 791

页数：8

共 37 条

[1]

Wilfert, Gutman, Sexually transmitted diseases, Textbook of Pediatric Infectious Diseases, pp. 608-621, (1987)

[2]

Kaufmann, Jones, Blount, Et al., Questionnaire study survey of reported early congenital syphilis, Sex Transm Dis, 4, pp. 135-139, (1977)

[3]

Benirschke, Kaufmann, Pathology of the Human Placenta, pp. 567-571, (1995)

[4]

Russell, Altshuler, Placental abnormalities of congenital syphilis: A neglected aid to diagnosis, Am J Dis Child, 128, pp. 160-163, (1974)

[5]

Schwartz, Zhang, Larsen, Et al., Placental pathology of congenital syphilis: Immunohistochemical aspects, Trophoblast Research, 8, pp. 223-229, (1994)

[6]

Altshuler, McAdams, The role of the placenta in fetal and perinatal pathology, Am J Obstet Gynecol, 113, pp. 616-626, (1972)

[7]

Malan, Woods, van der Elst, Et al., Relative placental weight in congenital syphilis, Placenta, 11, pp. 3-6, (1990)

[8]

McCord, A study of two hundred autopsies made on syphilitic fetuses, Am J Obstet Gynecol, 18, pp. 597-601, (1929)

[9]

Dorman, Sahyun, Identification and significance of spirochetes in the placenta: A report of 105 cases with positive findings, Am J Obstet Gynecol, 33, pp. 954-967, (1937)

[10]

Oppenheimer, Hardy, Congenital syphilis in the newborn infant: Clinical and pathological observations in recent cases, Hopkins Med J, 129, pp. 63-82, (1971)

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