SYNTHESIS OF BIS(ALPHA-AMINO ACIDS) BY PALLADIUM-CATALYZED ALLYLIC DOUBLE SUBSTITUTION

被引:16
作者
MAZON, A
NAJERA, C
EZQUERRA, J
PEDREGAL, C
机构
[1] UNIV ALICANTE,FAC CIENCIAS,DEPT QUIM ORGAN,E-03080 ALACANT,SPAIN
[2] CTR INVEST LILLY SA,E-28130 VALDEOLMOS,SPAIN
关键词
D O I
10.1016/0040-4039(95)01574-2
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The reaction of lithium enolate derived from benzophenone imine of glycine ethylester 1 with allylic dihalides 2 in the presence of a catalytic amount of Pd(Ph(3))(4) (5% mol) affords the corresponding bis(imino esters) 3. Subsequent hydrolysis of compounds 3 gives the corresponding bis(alpha-amino acids) 4. This methododology has been used to synthesise alpha,alpha'-diaminosuberic acid.
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页码:7697 / 7700
页数:4
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