THE HUMAN MDR1 (MULTIDRUG-RESISTANCE) GENE HARBORS A LONG HOMOPYRIMIDINE-CENTER-DOT-HOMOPURINE SEQUENCE NEXT TO A CLUSTER OF ALU REPEATED SEQUENCES IN INTRON-14

被引：7

作者：

PAULY, M ^{[1
]}

KAYSER, I ^{[1
]}

SCHMITZ, M ^{[1
]}

RIES, F ^{[1
]}

HENTGES, F ^{[1
]}

DICATO, M ^{[1
]}

机构：

[1] CTR HOSP LUXEMBOURG,SERV MED INTERNE,L-1210 LUXEMBOURG,LUXEMBOURG

来源：

GENE | 1995年 / 153卷 / 02期

关键词：

P-GLYCOPROTEIN; REPETITIVE SEQUENCES; NUCLEOTIDE SEQUENCE; GENE CLONING; RECOMBINANT DNA; GENE MAPPING;

D O I：

10.1016/0378-1119(95)00716-J

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

In order to identify specific DNA sequences useful as 'genetic landmarks' in the construction of a complete map of the human mdr1 (multidrug-resistance) gene, we investigated the introns in the central region. In intron 14, we identified a long stretch of a homopyrimidine homopurine sequence most probably adopting an unconventional DNA conformation, followed by a cluster of three Alu repeated sequences in an inverted orientation. Here, we describe the structure, formation and nucleotide sequence of these DNA elements.

引用

页码：299 / 300

页数：2

共 9 条

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[8] MULTIDRUG RESISTANCE OF DNA-MEDIATED TRANSFORMANTS IS LINKED TO TRANSFER OF THE HUMAN MDR1 GENE
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[J]. MOLECULAR AND CELLULAR BIOLOGY, 1986, 6 (11) : 4039 - 4045
[9] EXPRESSION OF A FULL-LENGTH CDNA FOR THE HUMAN MDR1 GENE CONFERS RESISTANCE TO COLCHICINE, DOXORUBICIN, AND VINBLASTINE
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