CYTOKINES ENHANCE THE PRODUCTION OF A CHEMOTACTIC FACTOR FOR POLYMORPHONUCLEAR LEUKOCYTES BY RAT RENAL GLOMERULAR EPITHELIOID CELLS

被引：27

作者：

WATANABE, K

NAKAGAWA, H

机构：

[1] Fac. Pharmaceutical Sciences, Toyama Med./Pharm. University, Sugitani

来源：

NEPHRON | 1990年 / 54卷 / 02期

关键词：

Chemoattractant; Dexamethasone; Epithelial cell; Glomeruli; Interleukin-1; Lipopolysaccharide; Neutrophil; NRK-52E cell; Tumor necrosis factor;

D O I：

10.1159/000185839

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Human recombinant interleukin-1β (IL-1) and tumor necrosis factor-α (TNF) dose-dependently enhanced the production of PMN chemotactic factor, which was trypsin-sensitive and heat-stable, by the epithelioid cells of rat renal glomeruli. Dexamethasone dose-dependently suppressed the chemoattractant production. Molecular weight and isoelectric point of this factor were 10 kDa and over 10, respectively. These results suggest that PMN migration to glomeruli occurs without participation of complement system when TNF or/and IL-1 are produced by activated cells in glomeruli.

引用

页码：169 / 175

页数：7

共 35 条

[1] RECOMBINANT HUMAN-TUMOR NECROSIS FACTOR-ALPHA - REGULATION OF N-FORMYLMETHIONYLLEUCYLPHENYLALANINE RECEPTOR AFFINITY AND FUNCTION ON HUMAN-NEUTROPHILS [J].