NOVEL 4-PHENOXY-2-(1-PIPERAZINYL)QUINAZOLINES AS POTENT ANTICONVULSIVE AND ANTIHYPOXIC AGENTS

被引：46

作者：

HORI, M

IEMURA, R

HARA, H

OZAKI, A

SUKAMOTO, T

OHTAKA, H

机构：

[1] Pharmaceuticals Research Center, Kanebo Ltd., Miyakojima-ku, Osaka, 534

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 1990年 / 38卷 / 03期

关键词：

anticonvulsive agent; antihypoxic effect; quinazoline; side effect; structure-activity relationship;

D O I：

10.1248/cpb.38.681

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of 4-phenoxy-2-(1-piperazinyl)quinazolines was synthesized and examined for anticonvulsive and antihypoxic activities. Many of the compounds exhibited potent anticonvulsive activity comparable to that of carbamazepine or phenytoin. Among them, 4-phenoxy-2(4-propy1-11-piperazinyl)quinazoline(5w) was selected as the most promising candidate antiepileptic drug with few side effects. It seemed that potent anticonvulsive activity was a prerequisite for potent antihypoxic activity. © 1990, The Pharmaceutical Society of Japan. All rights reserved.

引用

页码：681 / 687

页数：7

共 23 条

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