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DETOXICATION OF AFLATOXIN-B1 WITH GLUTATHIONE IN THE RAT
被引:44
作者
:
EMEROLE, GO
论文数:
0
引用数:
0
h-index:
0
机构:
NIEHS, RES TRIANGLE PK, NC 27709 USA
EMEROLE, GO
NESKOVIC, N
论文数:
0
引用数:
0
h-index:
0
机构:
NIEHS, RES TRIANGLE PK, NC 27709 USA
NESKOVIC, N
DIXON, RL
论文数:
0
引用数:
0
h-index:
0
机构:
NIEHS, RES TRIANGLE PK, NC 27709 USA
DIXON, RL
机构
:
[1]
NIEHS, RES TRIANGLE PK, NC 27709 USA
[2]
INEP, DEPT PESTICIDES, YU-11080 ZEMUN, YUGOSLAVIA
来源
:
XENOBIOTICA
|
1979年
/ 9卷
/ 12期
关键词
:
D O I
:
10.3109/00498257909042342
中图分类号
:
R9 [药学];
学科分类号
:
1007 ;
摘要
:
1. The deactivation of aflatoxin B1 by glutathione (GSH) has been investigated in rat. Binding of metabolites of aflatoxin B1 to [3H]glutathione in vitro with rat liver microsomes is insignificant. Incubation with rat liver 10000g supernatant results in increased binding. Under identical conditions, benzo(a)pyrene metabolites are bound to [3H]glutathione much more than is aflatoxin B1. 2. Pre-treatment of rats with aflatoxin B1 (2 mg/kg) caused depletion in GSH of rat liver with a minimum at 6 h but returning to above normal at 24 h. GSH S-transferase activity was marginally increased at 6 h also and returned to normal at 24 h. 3. Kidney GSH was not significantly decreased, but kidney GSH S-transferase activity showed a sudden increase in 6 h, returning to almost normal at 24 h. 4. Pre-treatment with benzo(a)pyrene (2 mg/kg) caused greater depletion of hepatic GSH than occurred with aflatoxin B1 but did not show any effect on kidney GSH. 5. Hepatic and kidney GSH S-transferase in benzo(a)pyrene-treated rats showed greatest activity at 2h followed by a gradual fall through 24 h. 6. GSH was therefore a less efficient nucleophile for aflatoxin B1 metabolites than for benzo(a)pyrene metabolites. © 1979 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
引用
收藏
页码:737 / 743
页数:7
相关论文
共 27 条
[1]
BOYLAND E, 1950, BIOCHEM SOC SYMP, V5, P40
[2]
BOYLAND E, 1965, BIOCHEM J, P94
[3]
Chasseaud L.F., 1976, GLUTATHIONE METABOLI, P77
[4]
TISSUE SULFHYDRYL GROUPS
ELLMAN, GL
论文数:
0
引用数:
0
h-index:
0
ELLMAN, GL
[J].
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS,
1959,
82
(01)
: 70
-
77
[5]
INDUCTION OF MUTATIONS IN DNA-REPAIR DEFICIENT BACTERIA BY A LIVER MICROSOMAL METABOLITE OF AFLATOXIN-B1
GARNER, RC
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV LEEDS,SCH MED,DEPT EXPTL PATHOL & CANC RES,LEEDS,YORKSHIRE,ENGLAND
UNIV LEEDS,SCH MED,DEPT EXPTL PATHOL & CANC RES,LEEDS,YORKSHIRE,ENGLAND
GARNER, RC
WRIGHT, CM
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV LEEDS,SCH MED,DEPT EXPTL PATHOL & CANC RES,LEEDS,YORKSHIRE,ENGLAND
UNIV LEEDS,SCH MED,DEPT EXPTL PATHOL & CANC RES,LEEDS,YORKSHIRE,ENGLAND
WRIGHT, CM
[J].
BRITISH JOURNAL OF CANCER,
1973,
28
(06)
: 544
-
551
[6]
BINDING OF [C-14]AFLATOXIN B1 TO CELLULAR MACROMOLECULES IN RAT AND HAMSTER
GARNER, RC
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV LEEDS,DEPT EXPTL PATHOL & CANC RES,171 WOODHOUSE LANE,LEEDS LS2 3AR,ENGLAND
UNIV LEEDS,DEPT EXPTL PATHOL & CANC RES,171 WOODHOUSE LANE,LEEDS LS2 3AR,ENGLAND
GARNER, RC
WRIGHT, CM
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV LEEDS,DEPT EXPTL PATHOL & CANC RES,171 WOODHOUSE LANE,LEEDS LS2 3AR,ENGLAND
UNIV LEEDS,DEPT EXPTL PATHOL & CANC RES,171 WOODHOUSE LANE,LEEDS LS2 3AR,ENGLAND
WRIGHT, CM
[J].
CHEMICO-BIOLOGICAL INTERACTIONS,
1975,
11
(02)
: 123
-
131
[7]
ENZYME-CATALYSED REACTIONS OF POLYCYCLIC HYDROCARBONS WITH DEOXYRIBONUCLEIC ACID AND PROTEIN IN VITRO
GROVER, PL
论文数:
0
引用数:
0
h-index:
0
GROVER, PL
SIMS, P
论文数:
0
引用数:
0
h-index:
0
SIMS, P
[J].
BIOCHEMICAL JOURNAL,
1968,
110
(01)
: 159
-
&
[8]
REACTIVITY OF K-REGION EPOXIDES OF SOME POLYCYCLIC HYDROCARBONS TOWARDS NUCLEIC ACIDS AND PROTEINS OF BHK 21 CELLS
GROVER, PL
论文数:
0
引用数:
0
h-index:
0
GROVER, PL
FORRESTER, JA
论文数:
0
引用数:
0
h-index:
0
FORRESTER, JA
SIMS, P
论文数:
0
引用数:
0
h-index:
0
SIMS, P
[J].
BIOCHEMICAL PHARMACOLOGY,
1971,
20
(06)
: 1297
-
+
[9]
BROMOBENZENE-INDUCED LIVER NECROSIS - PROTECTIVE ROLE OF GLUTATHIONE AND EVIDENCE FOR 3,4-BROMOBENZENE OXIDE AS HEPATOTOXIC METABOLITE
JOLLOW, DJ
论文数:
0
引用数:
0
h-index:
0
机构:
NHLI, LAB CHEM PHARMACOL, BETHESDA, MD 20014 USA
NHLI, LAB CHEM PHARMACOL, BETHESDA, MD 20014 USA
JOLLOW, DJ
MITCHELL, JR
论文数:
0
引用数:
0
h-index:
0
机构:
NHLI, LAB CHEM PHARMACOL, BETHESDA, MD 20014 USA
NHLI, LAB CHEM PHARMACOL, BETHESDA, MD 20014 USA
MITCHELL, JR
ZAMPAGLIONE, N
论文数:
0
引用数:
0
h-index:
0
机构:
NHLI, LAB CHEM PHARMACOL, BETHESDA, MD 20014 USA
NHLI, LAB CHEM PHARMACOL, BETHESDA, MD 20014 USA
ZAMPAGLIONE, N
GILLETTE, JR
论文数:
0
引用数:
0
h-index:
0
机构:
NHLI, LAB CHEM PHARMACOL, BETHESDA, MD 20014 USA
NHLI, LAB CHEM PHARMACOL, BETHESDA, MD 20014 USA
GILLETTE, JR
[J].
PHARMACOLOGY,
1974,
11
(03)
: 151
-
169
[10]
LAMBERT GH, 1976, BIOCHEM PHARMACOL, V25, P1777, DOI 10.1016/0006-2952(76)90415-9
←
1
2
3
→
共 27 条
[1]
BOYLAND E, 1950, BIOCHEM SOC SYMP, V5, P40
[2]
BOYLAND E, 1965, BIOCHEM J, P94
[3]
Chasseaud L.F., 1976, GLUTATHIONE METABOLI, P77
[4]
TISSUE SULFHYDRYL GROUPS
ELLMAN, GL
论文数:
0
引用数:
0
h-index:
0
ELLMAN, GL
[J].
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS,
1959,
82
(01)
: 70
-
77
[5]
INDUCTION OF MUTATIONS IN DNA-REPAIR DEFICIENT BACTERIA BY A LIVER MICROSOMAL METABOLITE OF AFLATOXIN-B1
GARNER, RC
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV LEEDS,SCH MED,DEPT EXPTL PATHOL & CANC RES,LEEDS,YORKSHIRE,ENGLAND
UNIV LEEDS,SCH MED,DEPT EXPTL PATHOL & CANC RES,LEEDS,YORKSHIRE,ENGLAND
GARNER, RC
WRIGHT, CM
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV LEEDS,SCH MED,DEPT EXPTL PATHOL & CANC RES,LEEDS,YORKSHIRE,ENGLAND
UNIV LEEDS,SCH MED,DEPT EXPTL PATHOL & CANC RES,LEEDS,YORKSHIRE,ENGLAND
WRIGHT, CM
[J].
BRITISH JOURNAL OF CANCER,
1973,
28
(06)
: 544
-
551
[6]
BINDING OF [C-14]AFLATOXIN B1 TO CELLULAR MACROMOLECULES IN RAT AND HAMSTER
GARNER, RC
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV LEEDS,DEPT EXPTL PATHOL & CANC RES,171 WOODHOUSE LANE,LEEDS LS2 3AR,ENGLAND
UNIV LEEDS,DEPT EXPTL PATHOL & CANC RES,171 WOODHOUSE LANE,LEEDS LS2 3AR,ENGLAND
GARNER, RC
WRIGHT, CM
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV LEEDS,DEPT EXPTL PATHOL & CANC RES,171 WOODHOUSE LANE,LEEDS LS2 3AR,ENGLAND
UNIV LEEDS,DEPT EXPTL PATHOL & CANC RES,171 WOODHOUSE LANE,LEEDS LS2 3AR,ENGLAND
WRIGHT, CM
[J].
CHEMICO-BIOLOGICAL INTERACTIONS,
1975,
11
(02)
: 123
-
131
[7]
ENZYME-CATALYSED REACTIONS OF POLYCYCLIC HYDROCARBONS WITH DEOXYRIBONUCLEIC ACID AND PROTEIN IN VITRO
GROVER, PL
论文数:
0
引用数:
0
h-index:
0
GROVER, PL
SIMS, P
论文数:
0
引用数:
0
h-index:
0
SIMS, P
[J].
BIOCHEMICAL JOURNAL,
1968,
110
(01)
: 159
-
&
[8]
REACTIVITY OF K-REGION EPOXIDES OF SOME POLYCYCLIC HYDROCARBONS TOWARDS NUCLEIC ACIDS AND PROTEINS OF BHK 21 CELLS
GROVER, PL
论文数:
0
引用数:
0
h-index:
0
GROVER, PL
FORRESTER, JA
论文数:
0
引用数:
0
h-index:
0
FORRESTER, JA
SIMS, P
论文数:
0
引用数:
0
h-index:
0
SIMS, P
[J].
BIOCHEMICAL PHARMACOLOGY,
1971,
20
(06)
: 1297
-
+
[9]
BROMOBENZENE-INDUCED LIVER NECROSIS - PROTECTIVE ROLE OF GLUTATHIONE AND EVIDENCE FOR 3,4-BROMOBENZENE OXIDE AS HEPATOTOXIC METABOLITE
JOLLOW, DJ
论文数:
0
引用数:
0
h-index:
0
机构:
NHLI, LAB CHEM PHARMACOL, BETHESDA, MD 20014 USA
NHLI, LAB CHEM PHARMACOL, BETHESDA, MD 20014 USA
JOLLOW, DJ
MITCHELL, JR
论文数:
0
引用数:
0
h-index:
0
机构:
NHLI, LAB CHEM PHARMACOL, BETHESDA, MD 20014 USA
NHLI, LAB CHEM PHARMACOL, BETHESDA, MD 20014 USA
MITCHELL, JR
ZAMPAGLIONE, N
论文数:
0
引用数:
0
h-index:
0
机构:
NHLI, LAB CHEM PHARMACOL, BETHESDA, MD 20014 USA
NHLI, LAB CHEM PHARMACOL, BETHESDA, MD 20014 USA
ZAMPAGLIONE, N
GILLETTE, JR
论文数:
0
引用数:
0
h-index:
0
机构:
NHLI, LAB CHEM PHARMACOL, BETHESDA, MD 20014 USA
NHLI, LAB CHEM PHARMACOL, BETHESDA, MD 20014 USA
GILLETTE, JR
[J].
PHARMACOLOGY,
1974,
11
(03)
: 151
-
169
[10]
LAMBERT GH, 1976, BIOCHEM PHARMACOL, V25, P1777, DOI 10.1016/0006-2952(76)90415-9
←
1
2
3
→