RECOMBINANT HUMAN IL-1-BETA AND TNF-ALPHA STIMULATE PRODUCTION OF IL-1-ALPHA AND IL-1-BETA BY VASCULAR SMOOTH-MUSCLE CELLS AND IL-1-ALPHA BY VASCULAR ENDOTHELIAL-CELLS

被引：23

作者：

SHINGU, M

NOBUNAGA, M

EZAKI, I

YOSHIOKA, K

机构：

[1] Department of Clinical Immunology, Medical Institute of Bioregulation, Kyushu University 69, 874, Tsurumihara, Beppu, Japan

来源：

LIFE SCIENCES | 1991年 / 49卷 / 03期

关键词：

D O I：

10.1016/0024-3205(91)90009-Z

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Vascular endothelial cells(EC) produced IL-1-alpha but not IL-1-beta into extracellular fluids. Vascular smooth muscle cells(SMC), on the other hand, produced both IL-1-alpha and IL-1-beta, and IL-1-beta produced was much higher than IL-1-alpha. The addition of recombinant human IL-1-beta or recombinant human TNF-alpha significantly enhanced IL-1-alpha production in EC, and IL-1-alpha and IL-1-beta production in SMC. IL-1-beta release was not observed even when EC were stimulated with TNF-alpha. These results suggest that the species of released form of IL-1 are different in different cell types and that cytokines enhance IL-1-alpha and IL-1-beta production in SMC and IL-1-alpha production in EC.

引用

页码：241 / 246

页数：6

共 19 条

[1]

ALBRIGHTSON CR, 1985, J IMMUNOL, V135, P1872

[2] INTERLEUKIN-1 ACTS ON CULTURED HUMAN VASCULAR ENDOTHELIUM TO INCREASE THE ADHESION OF POLYMORPHONUCLEAR LEUKOCYTES, MONOCYTES, AND RELATED LEUKOCYTE CELL-LINES [J].

BEVILACQUA, MP ;

POBER, JS ;

WHEELER, ME ;

COTRAN, RS ;

GIMBRONE, MA .

JOURNAL OF CLINICAL INVESTIGATION, 1985, 76 (05) :2003-2011

[3]

DURUM SK, 1985, ANNU REV IMMUNOL, V3, P263

[4] MONOCYTE ACTIVATION IN EARLY ONSET RHEUMATOID-ARTHRITIS [J].

FUJII, I ;

SHINGU, M ;

NOBUNAGA, M .

ANNALS OF THE RHEUMATIC DISEASES, 1990, 49 (07) :497-503

[5]

HARLAN JM, 1985, BLOOD, V65, P513

[6]

JAFFE EA, 1975, J CLIN INVEST, V52, P2745

[7]

KURTJONES EA, 1987, J IMMUNOL, V139, P2317

[8] INDUCIBLE INTERLEUKIN-1 GENE-EXPRESSION IN HUMAN VASCULAR SMOOTH-MUSCLE CELLS [J].

LIBBY, P ;

ORDOVAS, JM ;

BIRINYI, LK ;

AUGER, KR ;

DINARELLO, CA .

JOURNAL OF CLINICAL INVESTIGATION, 1986, 78 (06) :1432-1438

[9] CLONING, SEQUENCE AND EXPRESSION OF 2 DISTINCT HUMAN INTERLEUKIN-1 COMPLEMENTARY DNAS [J].

MARCH, CJ ;

MOSLEY, B ;

LARSEN, A ;

CERRETTI, DP ;

BRAEDT, G ;

PRICE, V ;

GILLIS, S ;

HENNEY, CS ;

KRONHEIM, SR ;

GRABSTEIN, K ;

CONLON, PJ ;

HOPP, TP ;

COSMAN, D .

NATURE, 1985, 315 (6021) :641-647

[10]

MIOSSEC P, 1986, J IMMUNOL, V136, P2486

← 1 2 →