PERMEABILITY OF THE HUMAN PLACENTA INVIVO TO 4 NON-METABOLIZED HYDROPHILIC MOLECULES

被引：33

作者：

BAIN, MD

COPAS, DK

TAYLOR, A

LANDON, MJ

STACEY, TE

机构：

[1] CLIN RES CTR,HARROW HA1 3UJ,MIDDX,ENGLAND

[2] UNIV SURREY,ROBENS INST,GUILDFORD GU2 5XH,SURREY,ENGLAND

来源：

JOURNAL OF PHYSIOLOGY-LONDON | 1990年 / 431卷

关键词：

D O I：

10.1113/jphysiol.1990.sp018343

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

1. Permeability of the human placenta to four permeants of different molecular size was measured at Caesarean section in seven normal full‐term pregnancies. 2. Placental clearance for mannitol was 8.7 +/‐ 1.1 ml min‐1 (mean +/‐ S.E.M.), lactulose 6.3 +/‐ 0.8, chromium ethylenediaminetetraacetic acid (CrEDTA) 3.7 +/‐ 0.5, and inulin 0.98 +/‐ 0.1. 3. The permeability data were analysed in terms of restricted diffusion through ‘notional’ water‐filled pores and found to be incompatible with a single population of uniform pores. © 1990 The Physiological Society

引用

页码：505 / 513

页数：9