EVALUATION OF THE HEPATOTOXIC POTENTIAL OF MINOCYCLINE

被引：20

作者：

BOCKER, R ^{[1
]}

ESTLER, CJ ^{[1
]}

LUDEWIGSANDIG, D ^{[1
]}

机构：

[1] UNIV ERLANGEN NURNBERG,INST PHARMACOL & TOXICOL,W-8520 ERLANGEN,GERMANY

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1991年 / 35卷 / 07期

关键词：

D O I：

10.1128/AAC.35.7.1434

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Minocycline (25 to 100-mu-g/g) dose dependently increased serum glutamic oxalacetic transaminase, urea, and bilirubin levels, and the hepatic triglyceride content in mice. In animals pretreated with phenobarbital to enhance minocycline metabolism, the effects on liver triglycerides were attenuated, while the changes in serum glutamic oxalacetic transaminase, urea, and bilirubin were enhanced. It is concluded that part of the toxic effects of minocycline may be produced by a metabolite of minocycline.

引用

页码：1434 / 1436

页数：3

共 11 条

[1]

BERGMEYER HU, 1970, METHODEN ENZYMATISCH, V2, P685

[2]

BOCKER R, 1981, ARZNEIMITTEL-FORSCH, V31-2, P2118

[3]

BOCKER R, 1982, ARZNEIMITTEL-FORSCH, V32-1, P237

[4] ACUTE HEPATIC-INJURY ASSOCIATED WITH MINOCYCLINE [J].

BURETTE, A ;

FINET, C ;

PRIGOGINE, T ;

DEROY, G ;

DELTENRE, M .

ARCHIVES OF INTERNAL MEDICINE, 1984, 144 (07) :1491-1492

[5] LIQUID-CHROMATOGRAPHIC DETERMINATION OF MINOCYCLINE IN HUMAN-SERUM [J].

DELEENHEER, AP ;

NELIS, HJCF .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1979, 68 (12) :1527-1530

[6] A RAPID AND PRECISE METHOD FOR THE DETERMINATION OF UREA [J].

FAWCETT, JK ;

SCOTT, JE .

JOURNAL OF CLINICAL PATHOLOGY, 1960, 13 (02) :156-159

[7]

Jendrassik L, 1938, BIOCHEM Z, V297, P81

[8]

LUDEWIGSANDIG D, 1988, THESIS U ERLANGEN NU

[9]

NELIS HJCF, 1981, LANCET, V2, P938

[10]

REDIN GS, 1967, ANTIMICROB AGENTS CH, V19, P371

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