THROMBOXANE RECEPTOR ANTAGONIST BMS-180291 - A NEW PRECLINICAL LEAD

被引：24

作者：

MISRA, RN

BROWN, BR

SHER, PM

PATEL, MM

HALL, SE

HAN, WC

BARRISH, JC

FLOYD, DM

SPRAGUE, PW

MORRISON, RA

RIDGEWELL, RE

WHITE, RE

DIDONATO, GC

HARRIS, DN

HEDBERG, A

SCHUMACHER, WA

WEBB, ML

OGLETREE, ML

机构：

[1] Bristol-Myers Squibb, Pharmaceutical Research Institute, N. J. 08543-4000, PO Box 4000, Princeton

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1992年 / 2卷 / 01期

关键词：

D O I：

10.1016/S0960-894X(00)80658-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis and initial pharmacology of interphenylene 7-oxabicyclo[2,2,1]heptane oxazole thromboxane (TxA2) receptor antagonist BMS-180291 is described. BMS-180291 has been characterized as an orally bioavailable, potent and selective TxA2 antagonist with a long duration of action.

引用

页码：73 / 76

页数：4

共 16 条

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