ANGIOTENSIN RECEPTOR SUBTYPES IN THE BRAIN

被引：101

作者：

STECKELINGS, UM ^{[1
]}

BOTTARI, SP ^{[1
]}

UNGER, T ^{[1
]}

机构：

[1] CIBA GEIGY AG,CARDIOVASC RES,CH-4002 BASEL,SWITZERLAND

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 1992年 / 13卷 / 09期

关键词：

D O I：

10.1016/0165-6147(92)90110-R

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Development of specific angiotensin II receptor ligands has recently provided evidence for the existence of two angiotensin II receptor subtypes, termed AT1 and AT2, which differ in their signal transduction mechanisms and in the effects they mediate. In brain, both receptor subtypes are present. Most of the known central actions of angiotensin II, for example the regulation of blood pressure and of electrolyte and water balance, seem to be mediated by the AT1 receptor, while the role of the AT2 receptor is still an enigma. This review by Thomas Unger and colleagues summarizes the current knowledge and latest hypotheses in this rapidly developing field.

引用

页码：365 / 368

页数：4

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