THE COMPETITIVE NMDA ANTAGONIST CGP40.116 ENHANCES L-DOPA RESPONSE IN MPTP-TREATED MARMOSETS

被引：42

作者：

WULLNER, U

KUPSCH, A

ARNOLD, G

RENNER, P

SCHEID, C

SCHEID, R

OERTEL, W

KLOCKGETHER, T

机构：

[1] UNIV MUNICH,INST PHYSIOL,PETTENKOFERSTR 12,W-8000 MUNICH 2,GERMANY

[2] UNIV TUBINGEN,DEPT NEUROL,W-7400 TUBINGEN,GERMANY

[3] LUDWIG MAXIMILIANS UNIV,DEPT NEUROL,W-8000 MUNICH 70,GERMANY

[4] UNIV MUNICH,MAX VON PETTENKOFER INST HYG & MED MICROBIOL,W-8000 MUNICH 2,GERMANY

来源：

NEUROPHARMACOLOGY | 1992年 / 31卷 / 07期

关键词：

MPTP; NMDA ANTAGONIST; CGP40.116; MARMOSET; LOCOMOTOR ACTIVITY;

D O I：

10.1016/0028-3908(92)90151-E

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Experiments in MPTP-treated non-human primates testing potential antiparkinsonian action have shown both, beneficial and adverse effects of gutamate receptor antagonists. To investigate this matter further, the novel competitive NMDA antagonist CGP40.116 was administered systemically to three adult MPTP-treated marmosets. When coadministered subcutaneously with a subthreshold dose of L-DOPA, 2 mg/kg, CGP40.116 25-250-mu-g/kg, increased locomotor activity. However, when administered alone, CGP40.116 had no effect on locomotor activity.

引用

页码：713 / 715

页数：3

共 14 条

[1] EXCITATORY AMINO-ACID BINDING-SITES IN THE BASAL GANGLIA OF THE RAT - A QUANTITATIVE AUTORADIOGRAPHIC STUDY
ALBIN, RL
MAKOWIEC, RL
HOLLINGSWORTH, ZR
DURE, LS
PENNEY, JB
YOUNG, AB
[J]. NEUROSCIENCE, 1992, 46 (01) : 35 - 48
[2] [Anonymous], 1987, BASAL GANGLIA 2
[3] REVERSAL OF EXPERIMENTAL PARKINSONISM BY LESIONS OF THE SUBTHALAMIC NUCLEUS
BERGMAN, H
WICHMANN, T
DELONG, MR
[J]. SCIENCE, 1990, 249 (4975) : 1436 - 1438
[4] ALLEVIATION OF PARKINSONISM BY ANTAGONISM OF EXCITATORY AMINO-ACID TRANSMISSION IN THE MEDIAL SEGMENT OF THE GLOBUS-PALLIDUS IN RAT AND PRIMATE
BROTCHIE, JM
MITCHELL, IJ
SAMBROOK, MA
CROSSMAN, AR
[J]. MOVEMENT DISORDERS, 1991, 6 (02) : 133 - 138
[5] EFFECTS OF CLASSICAL AND NOVEL AGENTS IN A MPTP-INDUCED REVERSIBLE MODEL OF PARKINSONS-DISEASE
CLOSE, SP
ELLIOTT, PJ
HAYES, AG
MARRIOTT, AS
[J]. PSYCHOPHARMACOLOGY, 1990, 102 (03) : 295 - 300
[6] PRIMATE MODELS OF DYSKINESIA - THE EXPERIMENTAL APPROACH TO THE STUDY OF BASAL GANGLIA-RELATED INVOLUNTARY MOVEMENT-DISORDERS
CROSSMAN, AR
[J]. NEUROSCIENCE, 1987, 21 (01) : 1 - 40
[7] EFFECT OF THE NMDA ANTAGONIST MK-801 ON MPTP-INDUCED PARKINSONISM IN THE MONKEY
CROSSMAN, AR
PEGGS, D
BOYCE, S
LUQUIN, MR
SAMBROOK, MA
[J]. NEUROPHARMACOLOGY, 1989, 28 (11) : 1271 - 1273
[8] CGP-37849 AND CGP-39551 - NOVEL AND POTENT COMPETITIVE N-METHYL-D-ASPARTATE RECEPTOR ANTAGONISTS WITH ORAL ACTIVITY
FAGG, GE
OLPE, HR
POZZA, MF
BAUD, J
STEINMANN, M
SCHMUTZ, M
PORTET, C
BAUMANN, P
THEDINGA, K
BITTIGER, H
ALLGEIER, H
HECKENDORN, R
ANGST, C
BRUNDISH, D
DINGWALL, JG
[J]. BRITISH JOURNAL OF PHARMACOLOGY, 1990, 99 (04) : 791 - 797
[9] THE AMPA RECEPTOR ANTAGONIST NBQX HAS ANTIPARKINSONIAN EFFECTS IN MONOAMINE-DEPLETED RATS AND MPTP-TREATED MONKEYS
KLOCKGETHER, T
TURSKI, L
HONORE, T
ZHANG, ZM
GASH, DM
KURLAN, R
GREENAMYRE, JT
[J]. ANNALS OF NEUROLOGY, 1991, 30 (05) : 717 - 723
[10] EXCITATORY AMINO-ACIDS AND THE BASAL GANGLIA - IMPLICATIONS FOR THE THERAPY OF PARKINSONS-DISEASE
KLOCKGETHER, T
TURSKI, L
[J]. TRENDS IN NEUROSCIENCES, 1989, 12 (08) : 285 - 286

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