ASSESSING THE SIGNIFICANCE OF CHROMOSOME-LOSS DATA - WHERE ARE SUPPRESSOR GENES FOR BLADDER-CANCER

被引：14

作者：

NEWTON, MA ^{[1
]}

WU, SQ ^{[1
]}

REZNIKOFF, CA ^{[1
]}

机构：

[1] UNIV WISCONSIN,CTR COMPREHENS CANC,DEPT HUMAN ONCOL,MADISON,WI 53792

来源：

STATISTICS IN MEDICINE | 1994年 / 13卷 / 08期

关键词：

D O I：

10.1002/sim.4780130805

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Cytogenetic analysis reveals alterations of chromosome structure (losses, gains, and rearrangements of genetic material) in bladder cancer cells generated using an in vitro/in vivo transformation system. To predict possible locations of bladder cancer suppressor genes, we performed a robust Bayesian analysis of the chromosome-loss data. We postulated a simple stochastic model to describe chromosome loss during tumour progression. Posterior computations are enabled by a dynamic simulation algorithm. Ordered by decreasing posterior probability of putatively harbouring a suppressor gene, we observe significant losses on chromosomes 3, 18, 13, 10, 11, and y.

引用

页码：839 / 858

页数：20

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