STEREOSELECTIVE ACCESS TO POLYFUNCTIONALIZED DECALINS

被引：10

作者：

POIREL, C ^{[1
]}

RENARD, PY ^{[1
]}

LALLEMAND, JY ^{[1
]}

机构：

[1] INRA,CNRA,MEDIATEURS CHIM LAB,F-78000 VERSAILLES,FRANCE

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 35期

关键词：

D O I：

10.1016/S0040-4039(00)78252-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

As a model of a stereoselective approach to ajugareptansin 1, a versatile and straightforward access to polyfunctionalized cis or trans decalins is presented. It is based on a Lewis acid-mediated addition of furan to the unsaturated ketoester 3 followed by oxidative opening of the furan to give cis decalins by an aldolisation process. Selective epimerization at carbons 5 or 10 is described and allows the access to the trans ring geometry.

引用

页码：6485 / 6488

页数：4

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