SYNERGISTIC EFFECT OF GANCICLOVIR AND FOSCARNET ON CYTOMEGALOVIRUS REPLICATION INVITRO

被引：109

作者：

MANISCHEWITZ, JF ^{[1
]}

QUINNAN, GV ^{[1
]}

LANE, HC ^{[1
]}

WITTEK, AE ^{[1
]}

机构：

[1] NIAID,CLIN IMMUNOL LAB,BETHESDA,MD 20892

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1990年 / 34卷 / 02期

关键词：

D O I：

10.1128/AAC.34.2.373

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Ganciclovir and foscarnet possess substantial activity against cytomegalovirus. Both exhibit dose-limiting toxicity, which reduces their clinical usefulness. We demonstrated synergistic inhibition of cytomegalovirus replication in vitro by ganciclovir and foscarnet. Reduced-dose combination therapy may provide a means to treat patients with cytomegalovirus infection while reducing drug toxicity.

引用

页码：373 / 375

页数：3

共 20 条

[1] Anhalt J.P., 1980, MANUAL CLIN MICROBIO, P478
[2] EFFECT OF ADENINE ARABINOSIDE ON CYTOMEGALOVIRUS INFECTIONS
CHIEN, LT
CANNON, NJ
WHITLEY, RJ
DIETHELM, AG
DISMUKES, WE
SCOTT, CW
BUCHANAN, RA
ALFORD, CA
[J]. JOURNAL OF INFECTIOUS DISEASES, 1974, 130 (01) : 32 - 39
[3] ELION GB, 1954, J BIOL CHEM, V208, P477
[4] CYTOMEGALO-VIRUS PNEUMONIA AFTER BONE-MARROW TRANSPLANTATION SUCCESSFULLY TREATED WITH THE COMBINATION OF GANCICLOVIR AND HIGH-DOSE INTRAVENOUS IMMUNE GLOBULIN
EMANUEL, D
CUNNINGHAM, I
JULESELYSEE, K
BROCHSTEIN, JA
KERNAN, NA
LAVER, J
STOVER, D
WHITE, DA
FELS, A
POLSKY, B
CASTROMALASPINA, H
PEPPARD, JR
BARTUS, P
HAMMERLING, U
OREILLY, RJ
[J]. ANNALS OF INTERNAL MEDICINE, 1988, 109 (10) : 777 - 782
[5] TREATMENT OF CYTOMEGALOVIRUS PNEUMONITIS WITH FOSCARNET (TRISODIUM PHOSPHONOFORMATE) IN PATIENTS WITH AIDS
FARTHING, C
ANDERSON, MG
ELLIS, ME
GAZZARD, BG
CHANAS, AC
[J]. JOURNAL OF MEDICAL VIROLOGY, 1987, 22 (02) : 157 - 162
[6] INFECTIOUS COMPLICATIONS OF THE ACQUIRED IMMUNE-DEFICIENCY SYNDROME
GOLD, JWM
ARMSTRONG, D
[J]. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1984, 437 (DEC) : 383 - 393
[7] INTRAVENOUS FOSCARNET FOR THE TREATMENT OF SEVERE CYTOMEGALO-VIRUS INFECTION IN ALLOGRAFT RECIPIENTS
KLINTMALM, G
LONNQVIST, B
OBERG, B
GAHRTON, G
LERNESTEDT, JO
LUNDGREN, G
RINGDEN, O
ROBERT, KH
WAHREN, B
GROTH, CG
[J]. SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES, 1985, 17 (02) : 157 - 163
[8] USE OF GANCICLOVIR TO TREAT SERIOUS CYTOMEGALOVIRUS INFECTIONS IN PATIENTS WITH AIDS
LASKIN, OL
STAHLBAYLISS, CM
KALMAN, CM
ROSECAN, LR
[J]. JOURNAL OF INFECTIOUS DISEASES, 1987, 155 (02) : 323 - 327
[9] EFFECT OF 9-(1,3-DIHYDROXY-2-PROPOXYMETHYL)GUANINE ON HUMAN CYTOMEGALOVIRUS REPLICATION INVITRO
MAR, EC
CHENG, YC
HUANG, ES
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1983, 24 (04) : 518 - 521
[10] EFFECT OF 9-(1,3-DIHYDROXY-2-PROPOXYMETHYL) GUANINE ON SERIOUS CYTOMEGALOVIRUS DISEASE IN 8 IMMUNOSUPPRESSED HOMOSEXUAL MEN
MASUR, H
LANE, HC
PALESTINE, A
SMITH, PD
MANISCHEWITZ, J
STEVENS, G
FUJIKAWA, L
MACHER, AM
NUSSENBLATT, R
BAIRD, B
MEGILL, M
WITTEK, A
QUINNAN, GV
PARRILLO, JE
ROOK, AH
ERON, LJ
PORETZ, DM
GOLDENBERG, RI
FAUCI, AS
GELMANN, EP
[J]. ANNALS OF INTERNAL MEDICINE, 1986, 104 (01) : 41 - 44

← 1 2 →