SYNTHESIS OF AZATHIA-ANALOGS OF PLATELET-ACTIVATING-FACTOR CONTAINING A METHIONINOL BACKBONE

被引：5

作者：

ZEIDLER, JM ^{[1
]}

ZIMMERMANN, W ^{[1
]}

ROTH, HJ ^{[1
]}

机构：

[1] UNIV TUBINGEN,INST PHARMAZEUT,AUF MORGENSTELLE 8,W-7400 TUBINGEN 1,GERMANY

来源：

CHEMISTRY AND PHYSICS OF LIPIDS | 1990年 / 56卷 / 2-3期

关键词：

PHOSPHOLIPID SYNTHESIS; PLATELET ACTIVATING FACTOR ANALOGS; AZATHIA-ANALOGS; ETHER LIPIDS; CHIRAL SULFUR COMPOUND;

D O I：

10.1016/0009-3084(90)90100-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The synthesis of azathia-analogues of the platelet activating factor containing a methioninol backbone is reported. The preparation starts with acylating methionine ethyl ester-HCl with palmitoyl chloride to form the amide linkage. Following ester reduction the phosphocholine part is introduced via 2-chloro-2-oxo-1,3,2-dioxaphospholane and subsequent ring opening with trimethylamine under pressure. Two related compounds, the sulfoxide and the sulfone, are obtained by oxidation with 3-chloroperbencoic acid. In addition the sulfoxide derivative is prepared starting with d- and l-methionine ethyl ester-HCl.

引用

页码：175 / 183

页数：9

共 21 条

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