RENAL TRANSPORT OF ORGANIC-ACIDS AND BASES IN AMINOGLYCOSIDE NEPHROTOXICITY

被引：9

作者：

BENNETT, WM

PLAMP, CE

PARKER, RA

GILBERT, DN

HOUGHTON, DC

PORTER, GA

机构：

[1] UNIV OREGON,HLTH SCI CTR,DEPT PATHOL,PORTLAND,OR 97201

[2] PROVIDENCE MED CTR,LESLIE GILBERT INFECTIOUS DIS RES LAB,PORTLAND,OR 97201

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1979年 / 16卷 / 02期

关键词：

D O I：

10.1128/AAC.16.2.231

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The effects of aminoglycoside antibiotics on the transport of p-aminohippurate and N-methylnicotinamide was measured in renal cortical slices of male Fischer rats. The p-aminohippurate transport pattern of early stimulation followed by late suppression appears to be characteristic of aminoglycosides which produce overt nephrotoxicity. In this rat model, neomycin is more nephrotoxic than gentamicin, which is more nephrotoxic than tobramycin.

引用

页码：231 / 233

页数：3