CONSERVATION OF HPV-16 E6/E7 ORF SEQUENCES IN A CERVICAL-CARCINOMA

被引：19

作者：

CONE, RW

MINSON, AC

SMITH, MR

MCDOUGALL, JK

机构：

[1] FRED HUTCHINSON CANC RES CTR, SEATTLE, WA 98104 USA

[2] FIRST HILL WOMENS CLIN, SEATTLE, WA USA

来源：

JOURNAL OF MEDICAL VIROLOGY | 1992年 / 37卷 / 02期

关键词：

HUMAN PAPILLOMAVIRUS; GENITAL; CANCER;

D O I：

10.1002/jmv.1890370205

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A cervical carcinoma that contained human papillomavirus (HPV)-16 homologous DNA was analyzed. Each tumor cell genome contained a single, incomplete copy of HPV-16 DNA. The E6 and E7 open reading frames (ORFs) were completely conserved relative to other published HPV-16 sequences. Much of the non-coding region (NCR) was free of base changes, including complete conservation of several regulatory elements. Multiple mutations were identified in the remaining integrated HPV-16 DNA, which was composed of parts of the L1 and E1 ORFs. The extraordinary conservation of the E6/E7 DNA sequence, as compared with other regions of the integrated HPV-16 DNA, supports the role of E6/E7 in tumorigenesis.

引用

页码：99 / 107

页数：9

共 30 条

[1] BOVINE PAPILLOMAVIRUS E2 TRANS-ACTIVATING GENE-PRODUCT BINDS TO SPECIFIC SITES IN PAPILLOMAVIRUS DNA
ANDROPHY, EJ
LOWY, DR
SCHILLER, JT
[J]. NATURE, 1987, 325 (6099) : 70 - 73
[2] STRUCTURAL AND TRANSCRIPTIONAL ANALYSIS OF HUMAN PAPILLOMAVIRUS TYPE-16 SEQUENCES IN CERVICAL-CARCINOMA CELL-LINES
BAKER, CC
PHELPS, WC
LINDGREN, V
BRAUN, MJ
GONDA, MA
HOWLEY, PM
[J]. JOURNAL OF VIROLOGY, 1987, 61 (04) : 962 - 971
[3] A NEW TYPE OF PAPILLOMAVIRUS DNA, ITS PRESENCE IN GENITAL CANCER BIOPSIES AND IN CELL-LINES DERIVED FROM CERVICAL-CANCER
BOSHART, M
GISSMANN, L
IKENBERG, H
KLEINHEINZ, A
SCHEURLEN, W
HAUSEN, HZ
[J]. EMBO JOURNAL, 1984, 3 (05) : 1151 - 1157
[4] SEQUENCE DUPLICATION AND INTERNAL DELETION IN THE INTEGRATED HUMAN PAPILLOMAVIRUS TYPE-16 GENOME CLONED FROM A CERVICAL-CARCINOMA
CHOO, KB
LEE, HH
PAN, CC
WU, SM
LIEW, LN
CHEUNG, WF
HAN, SH
[J]. JOURNAL OF VIROLOGY, 1988, 62 (05) : 1659 - 1666
[5] TRANSFORMATION OF NIH 3T3-CELLS BY A HUMAN C-SIS CDNA CLONE
CLARKE, MF
WESTIN, E
SCHMIDT, D
JOSEPHS, SF
RATNER, L
WONGSTAAL, F
GALLO, RC
REITZ, MS
[J]. NATURE, 1984, 308 (5958) : 464 - 467
[6] TRANSCRIPTIONAL REGULATION OF THE HUMAN PAPILLOMAVIRUS-16 E6-E7 PROMOTER BY A KERATINOCYTE-DEPENDENT ENHANCER, AND BY VIRAL E2 TRANSACTIVATOR AND REPRESSOR GENE-PRODUCTS - IMPLICATIONS FOR CERVICAL CARCINOGENESIS
CRIPE, TP
HAUGEN, TH
TURK, JP
TABATABAI, F
SCHMID, PG
DURST, M
GISSMANN, L
ROMAN, A
TUREK, LP
[J]. EMBO JOURNAL, 1987, 6 (12) : 3745 - 3753
[7] PAPILLOMAVIRUS SEQUENCES INTEGRATE NEAR CELLULAR ONCOGENES IN SOME CERVICAL CARCINOMAS
DURST, M
CROCE, CM
GISSMANN, L
SCHWARZ, E
HUEBNER, K
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (04) : 1070 - 1074
[8] THE HUMAN PAPILLOMA VIRUS-16 E7-ONCOPROTEIN IS ABLE TO BIND TO THE RETINOBLASTOMA GENE-PRODUCT
DYSON, N
HOWLEY, PM
MUNGER, K
HARLOW, E
[J]. SCIENCE, 1989, 243 (4893) : 934 - 937
[9] GALLOWAY DA, 1989, ADV VIRUS RES, V37, P125
[10] THE UPSTREAM REGULATORY REGION OF THE HUMAN PAPILLOMA VIRUS-16 CONTAINS AN E2-PROTEIN-INDEPENDENT ENHANCER WHICH IS SPECIFIC FOR CERVICAL-CARCINOMA CELLS AND REGULATED BY GLUCOCORTICOID HORMONES
GLOSS, B
BERNARD, HU
SEEDORF, K
KLOCK, G
[J]. EMBO JOURNAL, 1987, 6 (12) : 3735 - 3743

← 1 2 3 →