CONSERVATION OF HPV-16 E6/E7 ORF SEQUENCES IN A CERVICAL-CARCINOMA

被引:19
作者
CONE, RW
MINSON, AC
SMITH, MR
MCDOUGALL, JK
机构
[1] FRED HUTCHINSON CANC RES CTR, SEATTLE, WA 98104 USA
[2] FIRST HILL WOMENS CLIN, SEATTLE, WA USA
关键词
HUMAN PAPILLOMAVIRUS; GENITAL; CANCER;
D O I
10.1002/jmv.1890370205
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
A cervical carcinoma that contained human papillomavirus (HPV)-16 homologous DNA was analyzed. Each tumor cell genome contained a single, incomplete copy of HPV-16 DNA. The E6 and E7 open reading frames (ORFs) were completely conserved relative to other published HPV-16 sequences. Much of the non-coding region (NCR) was free of base changes, including complete conservation of several regulatory elements. Multiple mutations were identified in the remaining integrated HPV-16 DNA, which was composed of parts of the L1 and E1 ORFs. The extraordinary conservation of the E6/E7 DNA sequence, as compared with other regions of the integrated HPV-16 DNA, supports the role of E6/E7 in tumorigenesis.
引用
收藏
页码:99 / 107
页数:9
相关论文
共 30 条
  • [1] BOVINE PAPILLOMAVIRUS E2 TRANS-ACTIVATING GENE-PRODUCT BINDS TO SPECIFIC SITES IN PAPILLOMAVIRUS DNA
    ANDROPHY, EJ
    LOWY, DR
    SCHILLER, JT
    [J]. NATURE, 1987, 325 (6099) : 70 - 73
  • [2] STRUCTURAL AND TRANSCRIPTIONAL ANALYSIS OF HUMAN PAPILLOMAVIRUS TYPE-16 SEQUENCES IN CERVICAL-CARCINOMA CELL-LINES
    BAKER, CC
    PHELPS, WC
    LINDGREN, V
    BRAUN, MJ
    GONDA, MA
    HOWLEY, PM
    [J]. JOURNAL OF VIROLOGY, 1987, 61 (04) : 962 - 971
  • [3] A NEW TYPE OF PAPILLOMAVIRUS DNA, ITS PRESENCE IN GENITAL CANCER BIOPSIES AND IN CELL-LINES DERIVED FROM CERVICAL-CANCER
    BOSHART, M
    GISSMANN, L
    IKENBERG, H
    KLEINHEINZ, A
    SCHEURLEN, W
    HAUSEN, HZ
    [J]. EMBO JOURNAL, 1984, 3 (05) : 1151 - 1157
  • [4] SEQUENCE DUPLICATION AND INTERNAL DELETION IN THE INTEGRATED HUMAN PAPILLOMAVIRUS TYPE-16 GENOME CLONED FROM A CERVICAL-CARCINOMA
    CHOO, KB
    LEE, HH
    PAN, CC
    WU, SM
    LIEW, LN
    CHEUNG, WF
    HAN, SH
    [J]. JOURNAL OF VIROLOGY, 1988, 62 (05) : 1659 - 1666
  • [5] TRANSFORMATION OF NIH 3T3-CELLS BY A HUMAN C-SIS CDNA CLONE
    CLARKE, MF
    WESTIN, E
    SCHMIDT, D
    JOSEPHS, SF
    RATNER, L
    WONGSTAAL, F
    GALLO, RC
    REITZ, MS
    [J]. NATURE, 1984, 308 (5958) : 464 - 467
  • [6] TRANSCRIPTIONAL REGULATION OF THE HUMAN PAPILLOMAVIRUS-16 E6-E7 PROMOTER BY A KERATINOCYTE-DEPENDENT ENHANCER, AND BY VIRAL E2 TRANSACTIVATOR AND REPRESSOR GENE-PRODUCTS - IMPLICATIONS FOR CERVICAL CARCINOGENESIS
    CRIPE, TP
    HAUGEN, TH
    TURK, JP
    TABATABAI, F
    SCHMID, PG
    DURST, M
    GISSMANN, L
    ROMAN, A
    TUREK, LP
    [J]. EMBO JOURNAL, 1987, 6 (12) : 3745 - 3753
  • [7] PAPILLOMAVIRUS SEQUENCES INTEGRATE NEAR CELLULAR ONCOGENES IN SOME CERVICAL CARCINOMAS
    DURST, M
    CROCE, CM
    GISSMANN, L
    SCHWARZ, E
    HUEBNER, K
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (04) : 1070 - 1074
  • [8] THE HUMAN PAPILLOMA VIRUS-16 E7-ONCOPROTEIN IS ABLE TO BIND TO THE RETINOBLASTOMA GENE-PRODUCT
    DYSON, N
    HOWLEY, PM
    MUNGER, K
    HARLOW, E
    [J]. SCIENCE, 1989, 243 (4893) : 934 - 937
  • [9] GALLOWAY DA, 1989, ADV VIRUS RES, V37, P125
  • [10] THE UPSTREAM REGULATORY REGION OF THE HUMAN PAPILLOMA VIRUS-16 CONTAINS AN E2-PROTEIN-INDEPENDENT ENHANCER WHICH IS SPECIFIC FOR CERVICAL-CARCINOMA CELLS AND REGULATED BY GLUCOCORTICOID HORMONES
    GLOSS, B
    BERNARD, HU
    SEEDORF, K
    KLOCK, G
    [J]. EMBO JOURNAL, 1987, 6 (12) : 3735 - 3743