PURIFICATION AND CRYSTALLIZATION OF INTACT HUMAN RHINOVIRUS COMPLEXED WITH A NEUTRALIZING FAB

被引：7

作者：

SMITH, TJ

CHASE, ES

机构：

[1] Department of Biological Sciences, Purdue University, West Lafayette

来源：

VIROLOGY | 1992年 / 191卷 / 02期

关键词：

D O I：

10.1016/0042-6822(92)90235-H

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We report the first crystallization of an intact virion, human rhinovirus 14, complexed with the Fab fragment from a neutralizing antibody. These crystals diffract to at least 6.0 Å resolution. It has been suggested that Fab's and mAb's can induce large conformational changes in the capsid upon binding. The structure of this complex should enable us to detect the existence and role of such changes.© 1992 Academic Press, Inc. © 1992.

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页码：600 / 606

页数：7

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