ULTRASTRUCTURAL-LOCALIZATION OF UREASE OF HELICOBACTER-PYLORI

被引：30

作者：

BODE, G

MALFERTHEINER, P

LEHNHARDT, G

NILIUS, M

DITSCHUNEIT, H

机构：

[1] Department of Internal Medicine I, University of Ulm, Ulm, D-89081

来源：

MEDICAL MICROBIOLOGY AND IMMUNOLOGY | 1993年 / 182卷 / 05期

关键词：

D O I：

10.1007/BF00579622

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Helicobacter pylori urease was characterized by means of an enzyme histochemical electron microscopic technique. Ultrastructural analysis revealed no urease activity in one strain; in seven H. pylori strains (43.75 %), urease activity was associated with the cell membrane. Eight strains (50.0 %) showed reaction product located within the cytoplasm. Urease activity showed no correlation with localization of activity. Our results demonstrate that H. pylori urease is not uniform in all H. pylori strains, and differences in activity and localization of urease activity may account for different virulence activities.

引用

页码：233 / 242

页数：10

共 43 条

[1] MACROMOLECULAR STRUCTURE AND AGGREGATION STATES OF HELICOBACTER-PYLORI UREASE
AUSTIN, JW
DOIG, P
STEWART, M
TRUST, TJ
[J]. JOURNAL OF BACTERIOLOGY, 1991, 173 (18) : 5663 - 5667
[2] PATHOGENETIC IMPLICATIONS OF ULTRASTRUCTURAL FINDINGS IN CAMPYLOBACTER-PYLORI RELATED GASTRODUODENAL DISEASE
BODE, G
MALFERTHEINER, P
DITSCHUNEIT, H
[J]. SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 1988, 23 : 25 - 39
[3] ULTRASTRUCTURAL-LOCALIZATION OF UREASE IN OUTER-MEMBRANE AND PERIPLASM OF CAMPYLOBACTER-PYLORI
BODE, G
MALFERTHEINER, P
NILIUS, M
LEHNHARDT, G
DITSCHUNEIT, H
[J]. JOURNAL OF CLINICAL PATHOLOGY, 1989, 42 (07) : 778 - 779
[4] BORRIELLO SP, 1989, J MED MICROBIOL, V28, pR17
[5] BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3
[6] CHARACTERIZATION OF THE MORPHOLOGICAL CONVERSION OF HELICOBACTER-PYLORI FROM BACILLARY TO COCCOID FORMS
CATRENICH, CE
MAKIN, KM
[J]. SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 1991, 26 : 58 - 64
[7] LOSS OF UREASE ACTIVITY IN HELICOBACTER-MUSTELAE
COSTAS, M
OWEN, RJ
MORGAN, DD
GOODWIN, CS
[J]. LETTERS IN APPLIED MICROBIOLOGY, 1991, 13 (06) : 260 - 264
[8] EFFECT OF UREASE ON HELA-CELL VACUOLATION INDUCED BY HELICOBACTER-PYLORI CYTOTOXIN
COVER, TL
PURYEAR, W
PEREZPEREZ, GI
BLASER, MJ
[J]. INFECTION AND IMMUNITY, 1991, 59 (04) : 1264 - 1270
[9] DUNN BE, 1990, J BIOL CHEM, V265, P9464
[10] PURIFICATION AND CHARACTERIZATION OF HELICOBACTER-MUSTELAE UREASE
DUNN, BE
SUNG, CC
TAYLOR, NS
FOX, JG
[J]. INFECTION AND IMMUNITY, 1991, 59 (09) : 3343 - 3345

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